Tu Wenjun, Zhang Yuhan, Jiang Kunyu, Jiang Sha
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.
Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China.
Animals (Basel). 2023 Apr 18;13(8):1380. doi: 10.3390/ani13081380.
Osteocalcin (OCN) is synthesized and secreted by differentiating osteoblasts. In addition to its role in bone, OCN acts as a hormone in the pancreas, liver, muscle, fat, and other organs to regulate multiple pathophysiological processes including glucose homeostasis and adipic acid metabolism. Fat metabolic disorder, such as excessive fat buildup, is related to non-alcoholic fatty liver disease (NAFLD) in humans. Similarly, fatty liver hemorrhage syndrome (FLHS) is a metabolic disease in laying hens, resulting from lipid accumulation in hepatocytes. FLHS affects hen health with significant impact on poultry egg production. Many studies have proposed that OCN has protective function in mammalian NAFLD, but its function in chicken FLHS and related mechanism have not been completely clarified. Recently, we have revealed that OCN prevents laying hens from FLHS through regulating the JNK pathway, and some pathways related to the disease progression have been identified through both in vivo and vitro investigations. In this view, we discussed the current findings for predicting the strategy for using OCN to prevent or reduce FLHS impact on poultry production.
骨钙素（OCN）由分化中的成骨细胞合成并分泌。除了在骨骼中的作用外，OCN在胰腺、肝脏、肌肉、脂肪和其他器官中作为一种激素，调节包括葡萄糖稳态和脂肪酸代谢在内的多种病理生理过程。脂肪代谢紊乱，如脂肪过度堆积，与人类非酒精性脂肪性肝病（NAFLD）有关。同样，脂肪肝出血综合征（FLHS）是蛋鸡的一种代谢性疾病，由肝细胞内脂质蓄积引起。FLHS影响母鸡健康，对家禽产蛋有重大影响。许多研究表明OCN在哺乳动物NAFLD中具有保护作用，但其在鸡FLHS中的作用及相关机制尚未完全阐明。最近，我们发现OCN通过调节JNK通路预防蛋鸡患FLHS，并通过体内和体外研究确定了一些与疾病进展相关的通路。基于此，我们讨论了当前的研究结果，以预测使用OCN预防或减少FLHS对家禽生产影响的策略。
