Prakash Gaurav, Sharma Namrata, Chowdhary Vandana, Titiyal Jeewan Singh
Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
J Cataract Refract Surg. 2007 May;33(5):901-4. doi: 10.1016/j.jcrs.2006.12.029.
We report a case with asymmetric higher-order aberrations and wavefront profiles possibly leading to unilateral amblyopia. Stimulus deprivation, strabismus, substantially unequal refractive error, microtropia, and organic causes were ruled out. Keratographic assessment was similar bilaterally, but there was a between-eye difference by wavefront analysis. The predominant aberration in the left eye was defocus and in the right eye, x-axis trefoil. This resulted in different wavefront profiles and point-spread functions, which could have caused amblyopia during the critical age period. The case shows a previously unreported but logically probable cause of amblyopia. Since a single case can suggest the biological plausibility of a hypothesis but cannot prove the strength of the association, further research is required in patients with no cause or an insufficient explanation for amblyopia, especially patients with a mild refractive error difference.
我们报告了一例具有不对称高阶像差和波前像的病例，这可能导致单侧弱视。排除了形觉剥夺、斜视、屈光不正显著不等、微小斜视和器质性病因。角膜地形图评估双侧相似，但波前分析显示两眼之间存在差异。左眼的主要像差是散焦，右眼是x轴三叶像差。这导致了不同的波前像和点扩散函数，可能在关键年龄期导致了弱视。该病例显示了一种以前未报道但逻辑上可能的弱视病因。由于单个病例可以提示假设的生物学合理性，但不能证明关联的强度，因此对于无弱视病因或解释不充分的患者，尤其是屈光不正差异较小的患者，需要进一步研究。
