Generalov S I, Kostenko V S, Mareeva T E
Akush Ginekol (Mosk). 1991 Sep(9):21-3.
Central hemodynamics, free-radical lipid oxidation, anti-oxidant system, activities of lysosomal enzymes, and homeostasis system were studied in 86 pregnant women with congenital and acquired heart diseases. The studies have revealed a hypodynamic circulation type, activated lipid peroxidation processes, reduced level of alpha-tocopherol, a natural antioxidant, and activated coagulating and depressed anticoagulating system of the blood. These pathologic processes results in development of a mixed form of chronic hypoxia, augmenting with the progress of the heart condition. Assessment of these parameters helps timely start differentiated intensive care and improve labor outcome for the mother and fetus.
对86例患有先天性和后天性心脏病的孕妇的中心血流动力学、自由基脂质氧化、抗氧化系统、溶酶体酶活性和内稳态系统进行了研究。研究发现存在低动力循环类型、脂质过氧化过程激活、天然抗氧化剂α-生育酚水平降低以及血液凝固系统激活和抗凝系统抑制。这些病理过程导致混合性慢性缺氧的发展，并随着心脏病情的进展而加重。对这些参数的评估有助于及时开始进行有针对性的重症监护，并改善母婴的分娩结局。
