Chen Mingming, Shen Xuetong
Department of Carcinogenesis, Science Park Research Division, University of Texas M.D. Anderson Cancer Center, Smithville, Texas 78957, USA.
Curr Opin Cell Biol. 2007 Jun;19(3):326-30. doi: 10.1016/j.ceb.2007.04.009. Epub 2007 Apr 27.
Conventional actin and actin-related proteins (Arps) are members of the actin superfamily and are conserved throughout evolution. Although the cytoskeletal functions of cytoplasmic actin and Arps have been characterized extensively, the functions and mechanisms of nuclear actin and Arps are not yet well understood. Emerging evidence suggest that nuclear actin and Arps are involved in many nuclear processes, such as transcription and chromatin remodeling. Actin and Arps are subunits of multiple chromatin modifying complexes, and functionally contribute to chromatin modifications. Recent progress has been made in understanding nuclear actin and Arps in the context of chromatin regulation, suggesting potential mechanisms for their functions.
传统肌动蛋白和肌动蛋白相关蛋白（Arps）是肌动蛋白超家族的成员，在整个进化过程中保守。尽管细胞质肌动蛋白和Arps的细胞骨架功能已得到广泛表征，但核肌动蛋白和Arps的功能及机制尚未完全了解。新出现的证据表明，核肌动蛋白和Arps参与许多核过程，如转录和染色质重塑。肌动蛋白和Arps是多种染色质修饰复合物的亚基，并在功能上对染色质修饰有贡献。在染色质调控背景下理解核肌动蛋白和Arps方面已取得了最新进展，提示了其功能的潜在机制。
