Hawkins John A, Kouretas Peter C, Holubkov Richard, Williams Richard V, Tani Lloyd Y, Su Jason T, Lambert Linda M, Mart Christopher R, Puchalski Michael D, Minich L LuAnn
Division of Cardiothoracic Surgery, Department of Surgery, Primary Children's Medical Center, and the University of Utah, Salt Lake City, Utah 84113, USA.
J Thorac Cardiovasc Surg. 2007 May;133(5):1311-7. doi: 10.1016/j.jtcvs.2006.11.051. Epub 2007 Mar 29.
Repair of aortic valve insufficiency is difficult, and durability is relatively unknown in children. This study evaluates the intermediate-term results of repair of the systemic semilunar valve, including the native aortic valve, neoaortic valve (anatomic pulmonary), and truncal valve.
We reviewed the records of 54 children (aged 2 days to 18 years) who underwent repair of the functional aortic valve for moderate or greater insufficiency from 1991 to 2005. Valve anatomy was tricuspid aortic in 26 patients, bicuspid aortic in 11 patients, tricuspid neoaortic in 9 patients, bicuspid neoaortic in 1 patient, and truncal valve in 7 patients. Multiple surgical techniques were used in most of the 54 patients, including leaflet plication in 17, leaflet repair in 15, commissuroplasty in 32, pericardial cusp augmentation in 8, and sinus of Valsalva reduction in 3.
There was 1 early death and no late deaths. Actuarial freedom from reoperation was 68% at 5 years and 58% at 10 years. Freedom from aortic valve replacement was 82% at 5 years and 73% at 10 years. Duration of cardiopulmonary bypass was the most significant risk factor for reoperation with multivariate analysis. Of the 40 patients who have not undergone reoperation, 37 have had follow-up echocardiograms with the latest study (4.5 +/- 4.2 years) demonstrating trace to 1+ insufficiency in 23 patients, 1 to 2+ in 12 patients, 2 to 3+ in 1 patient, and 3 to 4+ in 1 patient.
Repair of the insufficient systemic semilunar valve offers acceptable 10-year freedom from reoperation and functional results, and should be considered for most children.
主动脉瓣关闭不全的修复手术难度较大,且在儿童患者中的耐久性相对未知。本研究评估了体循环半月瓣修复的中期结果,包括原生主动脉瓣、新主动脉瓣(解剖学上的肺动脉瓣)和动脉干瓣膜。
我们回顾了1991年至2005年间54例(年龄2天至18岁)因中度或重度关闭不全而接受功能性主动脉瓣修复的儿童患者的记录。瓣膜解剖结构为三尖瓣主动脉瓣的有26例患者,二叶式主动脉瓣的有11例患者,三尖瓣新主动脉瓣的有9例患者,二叶式新主动脉瓣的有1例患者,动脉干瓣膜的有7例患者。54例患者中的大多数采用了多种手术技术,包括17例的瓣叶折叠术、15例的瓣叶修复术、32例的交界切开术、8例的心包瓣叶扩大术和3例的主动脉窦缩小术。
有1例早期死亡,无晚期死亡。5年时再次手术的实际免发生率为68%,10年时为58%。5年时无需进行主动脉瓣置换的比例为82%,10年时为73%。多因素分析显示,体外循环时间是再次手术的最显著危险因素。在40例未接受再次手术的患者中,37例进行了随访超声心动图检查,最新研究(4.5±4.2年)显示,有23例患者存在微量至1+级关闭不全,12例患者为1至2+级,1例患者为2至3+级,1例患者为3至4+级。
对功能不全的体循环半月瓣进行修复,10年的再次手术免发生率和功能结果可接受,大多数儿童患者应考虑采用该方法。