保存人类心脏瓣膜用于儿童心脏瓣膜疾病的置换：过去、现在和未来。
Preservation of human heart valves for replacement in children with heart valve disease: past, present and future.
机构信息
Department of Pediatric Cardiothoracic Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, The Netherlands.
Department of Cardiovascular Cell Biology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.
出版信息
Cell Tissue Bank. 2024 Mar;25(1):67-85. doi: 10.1007/s10561-023-10076-2. Epub 2023 Feb 1.
Valvular heart disease affects 30% of the new-borns with congenital heart disease. Valve replacement of semilunar valves by mechanical, bioprosthetic or donor allograft valves is the main treatment approach. However, none of the replacements provides a viable valve that can grow and/or adapt with the growth of the child leading to re-operation throughout life. In this study, we review the impact of donor valve preservation on moving towards a more viable valve alternative for valve replacements in children or young adults.
瓣膜性心脏病影响 30%患有先天性心脏病的新生儿。通过机械、生物假体或供体同种异体瓣膜对半月瓣进行置换是主要的治疗方法。然而，没有一种替代品提供了一种可行的瓣膜，可以随着儿童的生长而生长和/或适应，从而导致一生中需要再次手术。在这项研究中，我们回顾了供体瓣膜保存对为儿童或年轻成人的瓣膜置换提供更可行的瓣膜替代物的影响。
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