Papadopoulou Alexandra K, Papachristou Dionysios J, Chatzopoulos Stavros A, Pirttiniemi Pertti, Papavassiliou Athanasios G, Basdra Efthimia K
Department of Orthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
FEBS Lett. 2007 May 15;581(10):2041-6. doi: 10.1016/j.febslet.2007.04.037. Epub 2007 Apr 25.
Experimental and clinical observations have proven the modulatory effects of mechanical loading on the development and maintenance of cartilage architecture. Here we examined the involvement of Sox-9, FGFR-3 and VEGF (pivotal factors controlling cartilage development and growth) in the mechano-transduction pathway of mandibular condylar cartilage by changing the dynamics of the transmitted load via changes in food hardness. To this end, condyle cartilage tissue of rats fed with hard or soft food was analyzed immunohistochemically at various time points. Our findings demonstrate that different mechanical loading conditions in condylar chondrocytes trigger differentiation-/maturation-related processes by affecting the expression levels of these factors, ultimately influencing condylar cartilage growth.
实验和临床观察已经证实了机械负荷对软骨结构发育和维持的调节作用。在此，我们通过改变食物硬度来改变传递负荷的动态，研究了Sox-9、FGFR-3和VEGF（控制软骨发育和生长的关键因子）在下颌髁突软骨机械转导途径中的作用。为此，在不同时间点对喂食硬食或软食的大鼠髁突软骨组织进行免疫组织化学分析。我们的研究结果表明，髁突软骨细胞中不同的机械负荷条件通过影响这些因子的表达水平触发与分化/成熟相关的过程，最终影响髁突软骨的生长。
