Niendam Tara A, Horwitz Jacqueline, Bearden Carrie E, Cannon Tyrone D
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, United States.
Schizophr Res. 2007 Jul;93(1-3):350-4. doi: 10.1016/j.schres.2007.03.009. Epub 2007 Apr 30.
Individuals with psychosis have prominent executive functioning (EF) deficits on neuropsychological tests, but their relationship to EF deficits in daily life is unclear. This study evaluates behavioral manifestations of EF deficits, assessed by the Behavioral Rating Inventory of Executive Functioning (BRIEF), and their clinical correlates in individuals at ultra-high-risk for psychosis (UHR). UHR subjects showed significantly elevated BRIEF scores, particularly on the Working Memory scale. BRIEF scores were associated with positive symptoms and functioning, but not with neuropsychological performance. The BRIEF appears to capture unique aspects of executive dysfunction, possibly associated with illness progression and functioning in the psychosis prodrome.
患有精神病的个体在神经心理学测试中存在明显的执行功能（EF）缺陷，但它们与日常生活中EF缺陷的关系尚不清楚。本研究评估了通过执行功能行为评定量表（BRIEF）评估的EF缺陷的行为表现及其在超高危精神病个体（UHR）中的临床相关性。UHR受试者的BRIEF评分显著升高，尤其是在工作记忆量表上。BRIEF评分与阳性症状和功能相关，但与神经心理学表现无关。BRIEF似乎捕捉到了执行功能障碍的独特方面，可能与精神病前驱期的疾病进展和功能有关。
