Canady J W, Squier C A, Kelly K M, Bardach J
Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City.
Ann Otol Rhinol Laryngol. 1991 Dec;100(12):962-5. doi: 10.1177/000348949110001202.
The present study investigates blood flow at several stages of expansion with and without enhancement by anticontractile agents (papaverine). Twelve 1-kg guinea pigs were divided into two groups. In group 1 were six animals undergoing tissue expansion without anticontractile agents, and in group 2 were six animals treated with a saturated solution of papaverine prior to expansion. Laser-Doppler velocimetry was used to monitor the changes in blood perfusion that occurred with each expansion. Animals pretreated with papaverine (group 2) maintained higher blood flow following inflation of the expander than untreated animals (group 1). This study provides physiologic evidence of the benefits of pharmacologic enhancement of the expansion process. Agents of this type may have a future role in the prevention of ischemic complications.
本研究调查了在有和没有抗收缩剂（罂粟碱）增强的情况下，扩张几个阶段的血流情况。12只1千克重的豚鼠被分为两组。第1组有6只动物在没有抗收缩剂的情况下进行组织扩张，第2组有6只动物在扩张前用罂粟碱饱和溶液处理。使用激光多普勒测速仪监测每次扩张时发生的血流灌注变化。用罂粟碱预处理的动物（第2组）在扩张器充气后比未处理的动物（第1组）维持更高的血流。本研究提供了药理学增强扩张过程益处的生理学证据。这类药物可能在预防缺血性并发症方面发挥未来作用。
