Krishnan Rajesh G, Ognjanovic Milos V, Crosier Jean, Coulthard Malcolm G
Department of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle, United Kingdom.
Perit Dial Int. 2007 May-Jun;27(3):296-9.
To determine whether gradually increasing the peritoneal dialysate fill volume from 10 to 40 mL/kg over 6 days, rather than commencing at 40 mL/kg, prevents hydrothorax in children and reverses it if present.
A review of children peritoneally dialyzed in a single center.
During the 20 years beginning June 1985, 416 children were peritoneally dialyzed, of which 327 (79%) had acute and 89 had end-stage renal failure. Among 253 children who had gradually increasing fill volumes, none developed acute hydrothoraces, but 13/163 (8%) who began with 40 mL/kg cycles did (p < 0.000, Fisher's exact test). These were diagnosed after a median (range) of 48 (6-72) hours and were predominantly right sided. Initially, we readily abandoned peritoneal dialysis; 2 were changed to hemodialysis. Subsequently, we found that peritoneal dialysis could be continued by using small volumes with the patients sitting up; cycle volumes were then gradually increased again. One pre-term baby died soon after developing an acute hydrothorax. One patient on chronic peritoneal dialysis developed an acute hydrothorax after forceful vomiting, but recovered after being dialyzed sitting up with low fills.
Acute hydrothorax can be prevented and treated using graduated cycle volumes, and is not a contraindication for peritoneal dialysis.
确定在6天内将腹膜透析液填充量从10 mL/kg逐渐增加至40 mL/kg,而非起始就采用40 mL/kg的填充量,是否能预防儿童胸腔积液,若已出现胸腔积液,能否使其逆转。
回顾在单一中心接受腹膜透析的儿童情况。
在1985年6月开始的20年间,416名儿童接受了腹膜透析,其中327名(79%)患有急性肾衰竭,89名患有终末期肾衰竭。在253名填充量逐渐增加的儿童中,无人发生急性胸腔积液,但在163名起始采用40 mL/kg循环量的儿童中,有13名(8%)发生了急性胸腔积液(p<0.000,Fisher精确检验)。这些胸腔积液在中位时间(范围)48(6 - 72)小时后被诊断出来,且主要发生在右侧。起初,我们轻易地放弃了腹膜透析;2名患儿改为血液透析。随后,我们发现让患儿坐起并使用小容量透析液可继续进行腹膜透析;然后再逐渐增加循环量。一名早产儿在发生急性胸腔积液后不久死亡。一名接受慢性腹膜透析的患者在剧烈呕吐后发生急性胸腔积液,但坐起并采用低填充量透析后康复。
采用逐渐增加的循环量可预防和治疗急性胸腔积液,且急性胸腔积液并非腹膜透析的禁忌证。