与呋塞米治疗相关的母体血流动力学变化。
Maternal hemodynamic changes associated with furosemide treatment.
作者信息
Carr Darcy B, Gavrila Daniel, Brateng Debra, Easterling Thomas R
机构信息
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA.
出版信息
Hypertens Pregnancy. 2007;26(2):173-8. doi: 10.1080/10641950701204489.
OBJECTIVE
To assess the pharmacodynamic effects of furosemide in pregnancy.
METHODS
Twenty-one pregnant women who received furosemide 20 mg daily had cardiac output (CO), stroke volume (SV), and total peripheral resistance (TPR) measured by Doppler technique before and after treatment.
RESULTS
Furosemide was initiated at 22.4 +/- 6.0 weeks gestation. CO and SV decreased (mean +/- SD: 1.2 +/- 0.2 L/min and 17+/-3 mL, respectively), whereas TPR increased (101+/-26 dyne.sec.cm(-5); p < 0.001 for all) after 2.9+/-1.4 weeks. Hemodynamics did not approach the expected mean for pregnancy.
CONCLUSIONS
While furosemide improved the hyperdynamic circulation in pregnancy, it did not lower blood pressure or cause clinically significant vasoconstriction.
目的
评估呋塞米在孕期的药效学作用。
方法
21名每日接受20毫克呋塞米治疗的孕妇，在治疗前后通过多普勒技术测量心输出量（CO）、每搏输出量（SV）和总外周阻力（TPR）。
结果
呋塞米于妊娠22.4±6.0周开始使用。2.9±1.4周后，CO和SV降低（分别为平均±标准差：1.2±0.2升/分钟和17±3毫升），而TPR升高（101±26达因·秒·厘米⁻⁵；所有p<0.001）。血流动力学未接近孕期预期均值。
结论
虽然呋塞米改善了孕期的高动力循环，但它并未降低血压或引起临床上显著的血管收缩。
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