酿酒酵母从人类志愿者肠道中清除的动力学以及这种酵母对无菌小鼠微生物定植抗性的影响。
Kinetics of Saccharomyces cerevisiae elimination from the intestines of human volunteers and effect of this yeast on resistance to microbial colonization in gnotobiotic mice.
作者信息
Pecquet S, Guillaumin D, Tancrede C, Andremont A
机构信息
Laboratoire de Microbiologie, Faculté de Pharmacie, Chatenay-Malabry, France.
出版信息
Appl Environ Microbiol. 1991 Oct;57(10):3049-51. doi: 10.1128/aem.57.10.3049-3051.1991.
Abstract
When healthy volunteers were given a daily dose of 3 x 10(8) life-dehydrated Saccharomyces cerevisiae cells for 5 days, the volunteers excreted 10(5) living yeast cells per g of feces at first, but the yeast cells disappeared within 5 days of the end of treatment. In gnotobiotic mice, S. cerevisiae administered alone colonized the intestinal tract but did not interfere with previous or subsequent colonization by a variety of potentially enteropathogenic microorganisms. When these microorganisms were present, the intestinal counts of S. cerevisiae were greatly reduced.
摘要
当健康志愿者连续5天每日服用3×10⁸个经冻干处理的酿酒酵母细胞时，志愿者最初每克粪便中排出10⁵个活酵母细胞，但在治疗结束后的5天内酵母细胞消失。在无菌小鼠中，单独给予的酿酒酵母可在肠道定植，但不干扰先前或随后多种潜在肠道致病微生物的定植。当存在这些微生物时，酿酒酵母的肠道计数会大大减少。
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