人体肠道菌群中的抗生素残留与耐药性。
Antibiotic residues and drug resistance in human intestinal flora.
作者信息
Corpet D E
出版信息
Antimicrob Agents Chemother. 1987 Apr;31(4):587-93. doi: 10.1128/AAC.31.4.587.
Abstract
The effect of residual levels of ampicillin on the drug resistance of fecal flora was studied in human volunteers given 1.5 mg of ampicillin orally per day for 21 days. This treatment failed to have any significant reproducible effect on the number of resistant Escherichia coli in their feces. The effect of continuous administration of small doses of ampicillin, chlortetracycline, or streptomycin in the drinking water was studied in gnotobiotic mice inoculated with a human fecal flora. In this animal model, which is free of many interfering factors, an increase in the fecal concentration of resistant E. coli was observed when the mice were given 0.5 microgram of ampicillin or chlortetracycline per ml of water. This model is therefore a sensitive system for testing the effect of antimicrobial drugs on the resistance characteristics of the intestinal flora.
摘要
对每天口服1.5毫克氨苄西林，持续21天的人类志愿者，研究了残余水平的氨苄西林对粪便菌群耐药性的影响。这种治疗方法对他们粪便中耐药性大肠杆菌的数量没有任何显著的可重复影响。对接种了人类粪便菌群的悉生小鼠，研究了在饮用水中连续给予小剂量氨苄西林、金霉素或链霉素的影响。在这个没有许多干扰因素的动物模型中，当给小鼠每毫升水0.5微克氨苄西林或金霉素时，观察到粪便中耐药性大肠杆菌的浓度增加。因此，这个模型是一个用于测试抗菌药物对肠道菌群耐药特性影响的敏感系统。
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