某些多环烃及其“K区”环氧化物在体外-体内致癌性测试系统中的活性。
The activities of some polycyclic hydrocarbons and their "K region" epoxides in an in vitro-in vivo carcinogenicity test system.
作者信息
Flaks A, Sims P
出版信息
Br J Cancer. 1975 Nov;32(5):604-9. doi: 10.1038/bjc.1975.267.
Benz(a)anthracene, 7,12-dimethylbenz(a)anthracene, dibenz(a)anthracene and benzo(a)pyrene and their related "K region" epoxides were tested for carcinogenic activities using a system in which mouse lung tissue was incubated in the presence of the test compound for 30 min and then implanted into isologous mice. Only 7,12-dimethylbenz(a)anthracene showed any marked carcinogenic activity under the conditions used, but all the compounds tested produced extensive proliferative outgrowths in the implanted tissues that may represent specific responses to the carcinogens.
使用一种系统对苯并(a)蒽、7,12-二甲基苯并(a)蒽、二苯并(a)蒽和苯并(a)芘及其相关的“K区域”环氧化物进行致癌活性测试，该系统是将小鼠肺组织在测试化合物存在的情况下孵育30分钟，然后植入同基因小鼠体内。在所使用的条件下，只有7,12-二甲基苯并(a)蒽表现出任何显著的致癌活性，但所有测试的化合物在植入组织中都产生了广泛的增殖性生长，这可能代表了对致癌物的特异性反应。
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