7-甲基苯并(a)蒽代谢物在一项使用小鼠肺组织的体外-体内致癌性试验中的活性。
The activity of 7-methylbenz(a)anthracene metabolites in an in vitro-in vivo carcinogenicity test using mouse lung tissue.
作者信息
Flaks A, Sims P
出版信息
Cancer Lett. 1977 Sep;3(3-4):163-7. doi: 10.1016/s0304-3835(77)95309-5.
PMID:409482
Abstract
7-Methylbenz(a)anthracene (7-MBA) and its 5,6-oxide and trans-5,6- and trans-8,9-dihydrodiol were tested for carcinogenic activity in a system in which mouse lung tissue was incubated in the presence of a test compound for 1 h and then implanted into isologous mice. All four compounds gave small yields of adenomas and in addition the 5,6-oxide gave two carcinomas.
摘要
对7-甲基苯并(a)蒽（7-MBA）及其5,6-氧化物、反式-5,6-二醇和反式-8,9-二醇进行了致癌活性测试。测试系统为将小鼠肺组织在受试化合物存在的情况下孵育1小时，然后植入同基因小鼠体内。所有这四种化合物都产生了少量腺瘤，此外，5,6-氧化物还产生了两例癌。
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