Viding Essi, Frick Paul J, Plomin Robert
Social Genetic and Developmental Psychiatry Centre, P080, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.
Br J Psychiatry Suppl. 2007 May;49:s33-8. doi: 10.1192/bjp.190.5.s33.
A callous and unemotional disposition is an indicator of early-onset antisocial behaviour.
To investigate the extent to which genetic influences contribute to the overlap between callous-unemotional traits and conduct problems in a large population sample of 7-year-old twins.
Teachers provided ratings of callous-unemotional traits and conduct problems for 3434 twin pairs from the Twins Early Development Study. Model-fitting analyses were performed across the continuum of scores and at the extremes.
The phenotypic relationship was primarily genetically mediated, both across the continuum and at the extremes and was substantial.
At 7 years of age, genetic influences on callous-unemotional traits overlap substantially with genetic influences on conduct problems. This combination should guide selection criteria in future molecular genetic studies.
冷酷无情的性情是早发性反社会行为的一个指标。
在一个由7岁双胞胎组成的大型群体样本中，调查基因影响在多大程度上导致了冷酷无情特质与行为问题之间的重叠。
教师对来自双胞胎早期发育研究的3434对双胞胎的冷酷无情特质和行为问题进行评分。在分数连续体上和极端情况下进行模型拟合分析。
表型关系主要由基因介导，无论是在连续体上还是在极端情况下，且这种关系很显著。
在7岁时，基因对冷酷无情特质的影响与基因对行为问题的影响有很大重叠。这种组合应指导未来分子遗传学研究的选择标准。
