血小板活化因子对大鼠体内脂质代谢的影响。高甘油三酯血症的成因。
Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.
作者信息
Evans R D, Ilic V, Williamson D H
机构信息
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, U.K.
出版信息
Biochem J. 1991 Dec 1;280 ( Pt 2)(Pt 2):541-3. doi: 10.1042/bj2800541.
Abstract
Administration of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF) did not alter the rate of triacylglycerol entry into the plasma. The gastrointestinal absorption of [1-14C]triolein was, however, inhibited by PAF, yet there was increased accumulation of [14C]lipid in the plasma and hypertriglyceridaemia. The half-life of injected [9,10(n)-3H]triolein in the plasma increased by 47%, and there was decreased accumulation of [3H]lipid in brown adipose tissue. This was accompanied by a decrease in lipoprotein lipase activity. The hypertriglyceridaemia induced by PAF appears to be mainly due to decreased peripheral removal, one important site affected being brown adipose tissue.
摘要
给予血小板活化因子（1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱；PAF）并未改变三酰甘油进入血浆的速率。然而，PAF抑制了[1-14C]三油精的胃肠道吸收，与此同时，血浆中[14C]脂质的蓄积增加，出现了高甘油三酯血症。注射的[9,10(n)-3H]三油精在血浆中的半衰期增加了47%，并且棕色脂肪组织中[3H]脂质的蓄积减少。这伴随着脂蛋白脂肪酶活性的降低。PAF诱导的高甘油三酯血症似乎主要是由于外周清除减少，棕色脂肪组织是受影响的一个重要部位。
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Biochem J. 1984 Oct 15;223(2):345-51. doi: 10.1042/bj2230345.
2
The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions.使用非离子洗涤剂（Triton WR 1339）来测定在不同生理条件下甘油三酯进入大鼠循环的速率。
J Physiol. 1967 May;190(2):321-32. doi: 10.1113/jphysiol.1967.sp008211.
3
[A new determination of the neutral fats in blood serum and tissue. I. Principles, procedure, and discussion of the method].[血清和组织中中性脂肪的新测定方法。I. 原理、步骤及方法讨论]
Klin Wochenschr. 1966 Mar 1;44(5):262-7. doi: 10.1007/BF01747716.
4
Blood flow rates through adipose tissues of unanesthetized rats.未麻醉大鼠脂肪组织的血流速率。
Am J Physiol. 1968 Feb;214(2):263-8. doi: 10.1152/ajplegacy.1968.214.2.263.
5
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