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Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.血小板活化因子对大鼠体内脂质代谢的影响。高甘油三酯血症的成因。
Biochem J. 1991 Dec 1;280 ( Pt 2)(Pt 2):541-3. doi: 10.1042/bj2800541.
2
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Biochem J. 1989 Jul 1;261(1):77-81. doi: 10.1042/bj2610077.
6
Tissue-specific effects of starvation and refeeding on the disposal of oral [1-14C]triolein in the rat during lactation and on removal of litter.饥饿和再喂养对哺乳期大鼠口服[1-14C]甘油三酯代谢及幼崽清除的组织特异性影响。
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Effect of platelet-activating factor on lipoprotein lipase and blood lipids.
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A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.青霉属 F33 代谢产物及其合成衍生物抑制乙酰辅酶 A：1-O- 烷基- sn-甘油-3-磷酸胆碱乙酰转移酶（血小板激活因子生物合成的关键酶）和角叉菜胶诱导的小鼠足肿胀。
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10
Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase.成年大鼠原代培养肝细胞中血小板活化因子通过涉及磷脂酶C和烷基单加氧酶的新途径进行代谢。
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本文引用的文献

1
Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state.胰岛素和胰高血糖素对泌乳大鼠乳腺脂肪生成的体内调节。胰岛素在转变为饥饿状态过程中的作用及作用位点。
Biochem J. 1984 Oct 15;223(2):345-51. doi: 10.1042/bj2230345.
2
The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions.使用非离子洗涤剂（Triton WR 1339）来测定在不同生理条件下甘油三酯进入大鼠循环的速率。
J Physiol. 1967 May;190(2):321-32. doi: 10.1113/jphysiol.1967.sp008211.
3
[A new determination of the neutral fats in blood serum and tissue. I. Principles, procedure, and discussion of the method].[血清和组织中中性脂肪的新测定方法。I. 原理、步骤及方法讨论]
Klin Wochenschr. 1966 Mar 1;44(5):262-7. doi: 10.1007/BF01747716.
4
Blood flow rates through adipose tissues of unanesthetized rats.未麻醉大鼠脂肪组织的血流速率。
Am J Physiol. 1968 Feb;214(2):263-8. doi: 10.1152/ajplegacy.1968.214.2.263.
5
Factors affecting lipoprotein metabolism.影响脂蛋白代谢的因素。
Adv Lipid Res. 1965;3:63-138.
6
Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.恶病质素的纯化，一种由内毒素诱导的RAW 264.7细胞分泌的脂蛋白脂肪酶抑制激素。
J Exp Med. 1985 May 1;161(5):984-95. doi: 10.1084/jem.161.5.984.
7
Profile of gastrointestinal damage induced by platelet-activating factor.血小板活化因子诱导的胃肠道损伤概况
Prostaglandins. 1986 Jul;32(1):137-41. doi: 10.1016/0090-6980(86)90156-5.
8
Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.肿瘤坏死因子诱导的大鼠肠坏死由血小板活化因子介导。
J Clin Invest. 1988 May;81(5):1328-31. doi: 10.1172/JCI113459.
9
Tumour necrosis factor alpha (cachectin) mimics some of the effects of tumour growth on the disposal of a [14C]lipid load in virgin, lactating and litter-removed rats.肿瘤坏死因子α（恶病质素）模拟肿瘤生长对未生育、哺乳期及摘除幼崽的大鼠处理[14C]脂质负荷的某些影响。
Biochem J. 1988 Dec 15;256(3):1055-8. doi: 10.1042/bj2561055.
10
Secretion and storage of newly synthesized hepatic triacylglycerol fatty acids in vivo in different nutritional states and in diabetes.新合成的肝脏三酰甘油脂肪酸在不同营养状态及糖尿病状态下的体内分泌与储存。
Biochem J. 1988 Nov 1;255(3):929-35. doi: 10.1042/bj2550929.

血小板活化因子对大鼠体内脂质代谢的影响。高甘油三酯血症的成因。

Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.

作者信息

Evans R D, Ilic V, Williamson D H

机构信息

Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, U.K.

出版信息

Biochem J. 1991 Dec 1;280 ( Pt 2)(Pt 2):541-3. doi: 10.1042/bj2800541.

DOI:10.1042/bj2800541
PMID:1747129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130582/
Abstract

Administration of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF) did not alter the rate of triacylglycerol entry into the plasma. The gastrointestinal absorption of [1-14C]triolein was, however, inhibited by PAF, yet there was increased accumulation of [14C]lipid in the plasma and hypertriglyceridaemia. The half-life of injected [9,10(n)-3H]triolein in the plasma increased by 47%, and there was decreased accumulation of [3H]lipid in brown adipose tissue. This was accompanied by a decrease in lipoprotein lipase activity. The hypertriglyceridaemia induced by PAF appears to be mainly due to decreased peripheral removal, one important site affected being brown adipose tissue.

摘要

给予血小板活化因子（1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱；PAF）并未改变三酰甘油进入血浆的速率。然而，PAF抑制了[1-14C]三油精的胃肠道吸收，与此同时，血浆中[14C]脂质的蓄积增加，出现了高甘油三酯血症。注射的[9,10(n)-3H]三油精在血浆中的半衰期增加了47%，并且棕色脂肪组织中[3H]脂质的蓄积减少。这伴随着脂蛋白脂肪酶活性的降低。PAF诱导的高甘油三酯血症似乎主要是由于外周清除减少，棕色脂肪组织是受影响的一个重要部位。