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1
Metabolic effects of platelet-activating factor in rats in vivo. Stimulation of hepatic glycogenolysis and lipogenesis.血小板活化因子对大鼠的体内代谢作用。刺激肝糖原分解和脂肪生成。
Biochem J. 1990 Jul 1;269(1):269-72. doi: 10.1042/bj2690269.
2
Comparison of effects of platelet-activating factor and tumour necrosis factor-alpha on lipid metabolism in adrenalectomized rats in vivo.血小板活化因子与肿瘤坏死因子-α对去肾上腺大鼠体内脂质代谢影响的比较
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3
The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells.
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4
Biological effects of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in the human neutrophil.1-酰基-2-乙酰基-sn-甘油-3-磷酸胆碱对人中性粒细胞的生物学效应
Biochim Biophys Acta. 1991 Jun 19;1084(1):41-7. doi: 10.1016/0005-2760(91)90053-k.
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Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.血小板活化因子对大鼠体内脂质代谢的影响。高甘油三酯血症的成因。
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6
Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism.
Am J Respir Cell Mol Biol. 1992 May;6(5):550-6. doi: 10.1165/ajrcmb/6.5.550.
7
Platelet-activating factor stimulates production of prostaglandin E2 in murine osteoblast-like cell line MC3T3-E1.血小板活化因子刺激小鼠成骨细胞样细胞系MC3T3-E1中前列腺素E2的产生。
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8
Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731.血小板活化因子（PAF）介导大鼠对可溶性免疫复合物的过敏反应。PAF受体拮抗剂L-652,731的研究。
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PAF increases hepatic vascular resistance and glycogenolysis in vivo.血小板活化因子在体内会增加肝血管阻力并促进糖原分解。
Am J Physiol. 1991 Mar;260(3 Pt 1):G471-80. doi: 10.1152/ajpgi.1991.260.3.G471.
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Differences in platelet-activating factor receptor mediated Ca++ response between hamster and guinea pig alveolar macrophages.仓鼠和豚鼠肺泡巨噬细胞中血小板活化因子受体介导的钙离子反应差异。
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1
Is hypertriglyceridemia a prognostic factor in sepsis?高甘油三酯血症是否是脓毒症的预后因素？
Ther Clin Risk Manag. 2014 Feb 27;10:147-50. doi: 10.2147/TCRM.S57791. eCollection 2014.
2
Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.血小板活化因子对大鼠体内脂质代谢的影响。高甘油三酯血症的成因。
Biochem J. 1991 Dec 1;280 ( Pt 2)(Pt 2):541-3. doi: 10.1042/bj2800541.

本文引用的文献

1
[A simple technic for extremely rapid freezing of large pieces of tissue].[一种用于极快速冷冻大块组织的简单技术]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;270:399-412.
2
Effects of inhibition of protein synthesis by cycloheximide on lipogenesis in mammary gland and liver of lactating rats.放线菌酮抑制蛋白质合成对泌乳大鼠乳腺和肝脏脂肪生成的影响。
Biochem J. 1982 May 15;204(2):417-23. doi: 10.1042/bj2040417.
3
Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin.缺血性肠坏死的实验模型。血小板活化因子和内毒素的作用。
Am J Pathol. 1983 Jul;112(1):127-35.
4
Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine.
J Biol Chem. 1984 Feb 10;259(3):1468-71.
5
Regulation of cholesterol synthesis in the liver and mammary gland of the lactating rat.泌乳大鼠肝脏和乳腺中胆固醇合成的调节
Biochem J. 1983 Jun 15;212(3):843-8. doi: 10.1042/bj2120843.
6
Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.乙酰甘油醚磷酸胆碱。一种肝磷酸肌醇代谢和糖原分解的强效激活剂。
J Biol Chem. 1983 Sep 10;258(17):10212-4.
7
The effect of acetylglyceryl ether phosphorylcholine on glycogenolysis and phosphatidylinositol 4,5-bisphosphate metabolism in rat hepatocytes.乙酰甘油醚磷酸胆碱对大鼠肝细胞糖原分解及磷脂酰肌醇-4,5-二磷酸代谢的影响
J Biol Chem. 1984 Jul 25;259(14):8685-8.
8
[A new determination of the neutral fats in blood serum and tissue. I. Principles, procedure, and discussion of the method].[血清和组织中中性脂肪的新测定方法。I. 原理、步骤及方法讨论]
Klin Wochenschr. 1966 Mar 1;44(5):262-7. doi: 10.1007/BF01747716.
9
A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties.一种依靠结合型和游离型激素部分的活性炭分离技术的灵敏、精确的血清胰岛素放射免疫测定法。
Acta Endocrinol (Copenh). 1972 Jul;70(3):487-509. doi: 10.1530/acta.0.0700487.
10
Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.肿瘤坏死因子-α在体内刺激大鼠肝脏脂肪生成。
J Clin Invest. 1987 Jul;80(1):184-90. doi: 10.1172/JCI113046.

血小板活化因子对大鼠的体内代谢作用。刺激肝糖原分解和脂肪生成。

Metabolic effects of platelet-activating factor in rats in vivo. Stimulation of hepatic glycogenolysis and lipogenesis.

作者信息

Evans R D, Ilic V, Williamson D H

机构信息

Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, U.K.

出版信息

Biochem J. 1990 Jul 1;269(1):269-72. doi: 10.1042/bj2690269.

DOI:10.1042/bj2690269
PMID:2165397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1131564/
Abstract
  1. The effects of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; PAF) on hepatic metabolism in vivo in rats were studied. 2. PAF stimulated synthesis of hepatic lipid (saponified and non-saponified) in a dose-dependent fashion and caused hypertriglyceridaemia. There was no effect of PAF on lipogenesis in isolated hepatocytes. 3. High doses of PAF also decreased hepatic glycogen. 4. All doses of PAF decreased plasma insulin, and this was accompanied by hyperglycaemia, except at the lowest dose. 5. The selective PAF-receptor antagonist L659.989 prevented the stimulation of lipogenesis, but indomethacin did not.
摘要
  1. 研究了血小板活化因子（1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱；PAF）对大鼠体内肝脏代谢的影响。2. PAF以剂量依赖性方式刺激肝脏脂质（皂化和非皂化）的合成，并导致高甘油三酯血症。PAF对分离的肝细胞中的脂肪生成没有影响。3. 高剂量的PAF也会降低肝糖原。4. 所有剂量的PAF都会降低血浆胰岛素水平，除最低剂量外，这还伴随着高血糖症。5. 选择性PAF受体拮抗剂L659.989可阻止脂肪生成的刺激，但吲哚美辛则不能。