血小板活化因子对大鼠的体内代谢作用。刺激肝糖原分解和脂肪生成。
Metabolic effects of platelet-activating factor in rats in vivo. Stimulation of hepatic glycogenolysis and lipogenesis.
作者信息
Evans R D, Ilic V, Williamson D H
机构信息
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, U.K.
出版信息
Biochem J. 1990 Jul 1;269(1):269-72. doi: 10.1042/bj2690269.
Abstract
- The effects of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; PAF) on hepatic metabolism in vivo in rats were studied. 2. PAF stimulated synthesis of hepatic lipid (saponified and non-saponified) in a dose-dependent fashion and caused hypertriglyceridaemia. There was no effect of PAF on lipogenesis in isolated hepatocytes. 3. High doses of PAF also decreased hepatic glycogen. 4. All doses of PAF decreased plasma insulin, and this was accompanied by hyperglycaemia, except at the lowest dose. 5. The selective PAF-receptor antagonist L659.989 prevented the stimulation of lipogenesis, but indomethacin did not.
摘要
- 研究了血小板活化因子（1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱；PAF）对大鼠体内肝脏代谢的影响。2. PAF以剂量依赖性方式刺激肝脏脂质（皂化和非皂化）的合成，并导致高甘油三酯血症。PAF对分离的肝细胞中的脂肪生成没有影响。3. 高剂量的PAF也会降低肝糖原。4. 所有剂量的PAF都会降低血浆胰岛素水平，除最低剂量外，这还伴随着高血糖症。5. 选择性PAF受体拮抗剂L659.989可阻止脂肪生成的刺激，但吲哚美辛则不能。
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