肿瘤坏死因子α（恶病质素）模拟肿瘤生长对未生育、哺乳期及摘除幼崽的大鼠处理[14C]脂质负荷的某些影响。
Tumour necrosis factor alpha (cachectin) mimics some of the effects of tumour growth on the disposal of a [14C]lipid load in virgin, lactating and litter-removed rats.
作者信息
Evans R D, Williamson D H
机构信息
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, U.K.
出版信息
Biochem J. 1988 Dec 15;256(3):1055-8. doi: 10.1042/bj2561055.
Abstract
Tumour necrosis factor alpha (cachectin) was administered to virgin, lactating and litter-removed rats, and subsequent disposal of an oral [1-14C]triolein (glycerol tri[1-14C]oleate) load examined. Absorption of the lipid and 14CO2 production were significantly depressed in all three groups. [14C]Lipid accumulation was decreased in carcass, liver and adipose tissue (brown and white) of virgin and litter-removed rats and the mammary gland of lactating rats. The plasma triacylglycerol concentration was increased in all three groups, and lipoprotein lipase activity was decreased in the white adipose tissue of virgin and litter-removed animals and in the mammary gland of lactating animals. Some, but not all, of these effects mimic tumour burden in the same physiological states [Evans & Williamson (1988) Biochem. J. 252, 65-72].
摘要
将肿瘤坏死因子α（恶病质素）给予未生育、哺乳期和摘除幼崽的大鼠，并随后检测口服[1-¹⁴C]三油酸甘油酯（甘油三[1-¹⁴C]油酸酯）负荷后的处理情况。脂质的吸收和¹⁴CO₂的产生在所有三组中均显著降低。[¹⁴C]脂质在未生育和摘除幼崽大鼠的胴体、肝脏和脂肪组织（棕色和白色）以及哺乳期大鼠的乳腺中的积累减少。所有三组的血浆三酰甘油浓度均升高，并且脂蛋白脂肪酶活性在未生育和摘除幼崽动物的白色脂肪组织以及哺乳期动物的乳腺中降低。这些效应中的一些（但不是全部）在相同生理状态下模拟肿瘤负荷[埃文斯和威廉姆森（1988年）《生物化学杂志》252卷，65 - 72页]。
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Sequential changes in the activities of lipoprotein lipase and lipogenic enzymes during tumor growth in rats.大鼠肿瘤生长过程中脂蛋白脂肪酶和脂肪生成酶活性的顺序变化。
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Cachectin: more than a tumor necrosis factor.恶病质素：不仅仅是一种肿瘤坏死因子。
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Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.啮齿动物对高剂量重组肿瘤坏死因子-α胃肠道效应产生部分耐受性的发展。
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Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells.人重组肿瘤坏死因子抑制3T3-L1细胞中的脂蛋白脂肪酶活性并刺激脂肪分解。
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The effects of recombinant tumour necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations.重组肿瘤坏死因子（恶病质素）对分离的大鼠脂肪细胞、肝细胞和肌肉制剂代谢的影响。
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