Mouécoucou J, Villaume C, Bau H M, Nicolas J P, Méjean L
INSERM U 308, Unité de recherches sur les mécanismes de régulation du comportement alimentaire, Nancy, France.
Reprod Nutr Dev. 1991;31(4):377-88.
Male 21-d-old Wistar rats were fed over 3 experimental periods. During the first period of 4 wk, diets contained 10% casein or defatted soy flour proteins, with or without 0.5, 1, 2 or 3% sodium alginate or sodium carrageenan, and were heated. During the second period, they were fed a standard diet for 16 wk with 17% proteins, and during the third period, they received the same diet as in the first period, but with 20% proteins. Rat body weights were measured throughout the study period; plasma lipid levels were then determined after fasting. Presence of sodium alginate in the diet had no effect on growth, but rats fed carrageenan presented growth retardation at the end of the experimental period, which was not altered by refeeding the standard diet. Sodium alginate did not modify rat triglyceridemia, except at the 1% level. Carrageenan had a hypotriglyceridemic effect. Alginate and carrageenan had no effect on blood cholesterol. Compared to soybean protein, casein intake did not increase plasma cholesterol levels as generally described. The effect of carrageenans on growth and plasma triglyceride levels could be a result of their physico-chemical properties.
21日龄雄性Wistar大鼠经过3个实验阶段喂养。在为期4周的第一阶段，日粮含有10%的酪蛋白或脱脂大豆粉蛋白，添加或不添加0.5%、1%、2%或3%的海藻酸钠或角叉菜胶，并进行加热处理。在第二阶段，它们被喂食含17%蛋白质的标准日粮16周，在第三阶段，它们接受与第一阶段相同的日粮，但蛋白质含量为20%。在整个研究期间测量大鼠体重；禁食后测定血浆脂质水平。日粮中添加海藻酸钠对生长没有影响，但喂食角叉菜胶的大鼠在实验期结束时出现生长迟缓，重新喂食标准日粮后这种情况未改变。海藻酸钠除了在1%的添加水平外，对大鼠甘油三酯血症没有影响。角叉菜胶有降甘油三酯的作用。海藻酸钠和角叉菜胶对血液胆固醇没有影响。与大豆蛋白相比，酪蛋白摄入并未如通常所描述的那样增加血浆胆固醇水平。角叉菜胶对生长和血浆甘油三酯水平的影响可能是其物理化学性质所致。
