Ludka O, Spinar J, Vítovcová L, Sobotová D, Spinarová L, Vítovec J, Tomandl J
Interní kardiologická klinika Lékarské fakulty MU a FN Brno.
Vnitr Lek. 2007 Jan;53(1):38-45.
We have followed 99 patients with end stage renal failure, treated by regular haemodialysis. Chronic renal failure is frequently accompanied by chronic heart failure (over 50%), especially by heart failure with preserved ejection fraction. Patients treated by regular haemodialysis had a tendency to cardiomegaly (51%), mild systolic dysfunction of the left ventricle (mean LVEF 53%) and diastolic dysfunction (88%) of the hypertrophic left ventricle. They had also activated endothelin and neurohumoral system. Only 3% of the patients had normal values of Nt-proBNP and big endothelin. The plasma level of Nt-proBNP in haemodialysed patients correlated with cardiothoracic ratio and with ejection fraction. The plasma level of big endothelin correlated only with cardiothoracic ratio.
我们对99例接受常规血液透析治疗的终末期肾衰竭患者进行了随访。慢性肾衰竭常伴有慢性心力衰竭（超过50%），尤其是射血分数保留的心力衰竭。接受常规血液透析治疗的患者有心脏扩大的倾向（51%）、左心室轻度收缩功能障碍（平均左心室射血分数53%）以及肥厚左心室的舒张功能障碍（88%）。他们还激活了内皮素和神经体液系统。只有3%的患者Nt-proBNP和大内皮素值正常。血液透析患者的血浆Nt-proBNP水平与心胸比率及射血分数相关。大内皮素的血浆水平仅与心胸比率相关。
