Barton Susan H, Kelly Darlene G, Murray Joseph A
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Gastroenterol Clin North Am. 2007 Mar;36(1):93-108, vi. doi: 10.1016/j.gtc.2007.01.006.
Celiac disease is characterized by small bowel enteropathy, precipitated in genetically susceptible individuals by the ingestion of "gluten," which is a term used to encompass the storage proteins of wheat, rye, and barley. Although the intestine heals with removal of gluten from the diet, the intolerance is permanent and the damage recurs if gluten is reintroduced. This damage causes a wide variety of consequence including maldigestion and malabsorption, resulting in the characteristic, although not universal, features of malnutrition. This article examines recent advances in the understanding of the spectrum of celiac disease, illustrates the impact of celiac disease on nutrition, and describes approaches to the management of the disease.
乳糜泻的特征是小肠肠病，在遗传易感个体中，因摄入“麸质”而诱发，麸质是一个用于涵盖小麦、黑麦和大麦储存蛋白的术语。虽然通过从饮食中去除麸质，肠道会愈合，但不耐受是永久性的，如果重新摄入麸质，损伤会再次出现。这种损伤会导致多种后果，包括消化不良和吸收不良，从而导致营养不良的典型特征（尽管并非普遍存在）。本文探讨了对乳糜泻谱系理解的最新进展，阐述了乳糜泻对营养的影响，并描述了该疾病的管理方法。
