Ballesteros María L, Bianchi Guillermo E, Carranza Miriam, Bistoni María A
Cátedra de Diversidad Animal II, Universidad Nacional de Córdoba, Córdoba, Argentina.
J Environ Sci Health B. 2007 May;42(4):351-7. doi: 10.1080/03601230701309577.
Toxicity tests using adult specimens of Jenynsia multidentata were carried out during 96 hours in order to determine the lethal concentration (LC50) of endosulfan. Histological alterations were determined in gills and liver. Gill damage was quantified as secondary lamellae thickness. The 96 hr LC50 values were significantly different between males (0.719 microg x L(-1)) and females (1.317 microg x L(-1)). The sex difference was attributed to the dimorphism in the lipid content in females (2.16%) and males (1.79%). Histological alterations in gills included hypertrophy and lifting of the epithelium of the secondary lamellae and aneurisms. These alterations caused a significant increase of the secondary lamellae thickness in treatment versus control fish. Finally, reversible histological alterations (such as hydropic degeneration and dilation of sinusoids) were observed in the liver of exposed fish as well as an irreversible change such as necrosis at the highest concentrations.
为了确定硫丹的致死浓度（LC50），使用多齿珍妮丽鱼的成年样本进行了96小时的毒性试验。测定了鳃和肝脏的组织学变化。鳃损伤以次生鳃小片厚度进行量化。雄性（0.719微克×升⁻¹）和雌性（1.317微克×升⁻¹）的96小时LC50值存在显著差异。这种性别差异归因于雌性（2.16%）和雄性（1.79%）脂质含量的二态性。鳃的组织学变化包括次生鳃小片上皮的肥大和隆起以及动脉瘤。与对照鱼相比，这些变化导致处理组鱼的次生鳃小片厚度显著增加。最后，在暴露鱼的肝脏中观察到可逆的组织学变化（如空泡变性和血窦扩张）以及在最高浓度下出现的不可逆变化如坏死。
