Laboratory of Animal Diversity II, Faculty of Exact, Physical, and Natural Sciences, National University of Córdoba, Av. Vélez Sársfield 299, CP 5000, Córdoba, Argentina.
Arch Environ Contam Toxicol. 2012 Jan;62(1):107-17. doi: 10.1007/s00244-011-9686-7. Epub 2011 Jun 4.
Roundup is the most popular commercial glyphosate formulation applied in the cultivation of genetically modified glyphosate-resistant crops. The aim of this study was to evaluate the histological lesions of the neotropical native fish, Jenynsia multidentata, in response to acute and subchronic exposure to Roundup and to determine if subchronic exposure to the herbicide causes changes in male sexual activity of individuals exposed to a sublethal concentration (0.5 mg/l) for 7 and 28 days. The estimated 96-h LC50 was 19.02 mg/l for both male and female fish. Gill and liver histological lesions were evaluated through histopathological indices allowing quantification of the histological damages in fish exposed to different concentrations of the herbicide. Roundup induced different histological alterations in a concentration-dependent manner. In subchronic-exposure tests, Roundup also altered normal histology of the studied organs and caused a significant decrease in the number of copulations and mating success in male fish exposed to the herbicide. It is expected that in natural environments contaminated with Roundup, both general health condition and reproductive success of J. multidenatata could be seriously affected.
草甘膦是最受欢迎的商业草甘膦制剂，用于种植抗草甘膦的转基因作物。本研究旨在评估新热带本地鱼类詹尼西亚多齿脂鲤（Jenynsia multidentata）对急性和亚慢性接触草甘膦的组织损伤，并确定亚慢性接触除草剂是否会导致暴露于亚致死浓度（0.5mg/L）的个体的雄性性活动发生变化暴露 7 天和 28 天。雄性和雌性鱼类的估计 96 小时 LC50 均为 19.02mg/L。通过组织病理学指数评估了鳃和肝脏的组织损伤，允许定量评估暴露于不同浓度除草剂的鱼类的组织损伤。草甘膦以浓度依赖的方式引起不同的组织改变。在亚慢性暴露试验中，草甘膦还改变了研究器官的正常组织学结构，并导致暴露于除草剂的雄性鱼类的交配次数和交配成功率显著降低。预计在被草甘膦污染的自然环境中，詹尼西亚多齿脂鲤的一般健康状况和繁殖成功率都可能受到严重影响。
