Turecek Frantisek
Department of Chemistry, Bagley Hall, University of Washington, Seattle, WA 98195-1700, USA.
Mass Spectrom Rev. 2007 Jul-Aug;26(4):563-82. doi: 10.1002/mas.20137.
This review deals with copper complexes of a variety of organic and bioorganic molecules that have been produced as gas-phase ions by electrospray and other ionization methods and studied experimentally by mass spectrometry and theoretically by ab initio and density functional theory computations. Ternary complexes of Cu((II)) allow one to modify the oxidation state and coordination sphere of the copper ion and thus induce novel fragmentations that involve redox and radical-based reactions. Structure elucidation, distinction, and quantitation of leucine and isoleucine isomers in peptides, distinction of enantiomers in chiral compounds, and sensitive detection of antibiotics are some of the highlights of mass spectrometry of ternary copper complexes. Binary copper complexes are mainly represented by Cu((I)) species in which the copper ion displays the properties of a weak Lewis acid.
本综述涉及通过电喷雾和其他电离方法产生的气相离子形式的各种有机和生物有机分子的铜配合物，并通过质谱进行实验研究，以及通过从头算和密度泛函理论计算进行理论研究。铜（II）的三元配合物能够改变铜离子的氧化态和配位球，从而引发涉及氧化还原和基于自由基反应的新型碎片化。肽中亮氨酸和异亮氨酸异构体的结构解析、区分和定量，手性化合物中对映体的区分，以及抗生素的灵敏检测是三元铜配合物质谱分析的一些亮点。二元铜配合物主要由铜（I）物种代表，其中铜离子表现出弱路易斯酸的性质。
