C2对称双亚砜作为苯甲酰腙烯丙基化反应中的有机催化剂：间隔基和浓度效应
C2-symmetric bissulfoxides as organocatalysts in the allylation of benzoyl hydrazones: spacer and concentration effects.
作者信息
Fernández Inmaculada, Valdivia Victoria, Leal Manuel Pernía, Khiar Noureddine
机构信息
Departamento de Química OrgAnica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.
出版信息
Org Lett. 2007 May 24;9(11):2215-8. doi: 10.1021/ol070729d. Epub 2007 May 3.
PMID:17474752
Abstract
A comparative study on the allylation of a benzoyl hydrazone with allyl trichlorosilane using monosulfoxides, methylene-bridged C2-symmetric bissulfoxides, and ethylene-bridged C2-symmetric bissulfoxides shows that the enantioselectivity of the process is highly dependent on the spacer between the two sulfinyl sulfurs and the concentration of the reaction.
摘要
一项使用单亚砜、亚甲基桥连的C2对称双亚砜和乙烯桥连的C2对称双亚砜，对苯甲酰腙与烯丙基三氯硅烷进行烯丙基化反应的比较研究表明，该反应过程的对映选择性高度依赖于两个亚磺酰硫之间的间隔基团以及反应浓度。
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