South Timothy, Deng Chao, Huang Xu-Feng
Neurobiology Research Centre for Metabolic and Psychiatric Disorders, School of Health Sciences, University of Wollongong, Northfields Avenue, NSW 2522, Australia.
Behav Brain Res. 2007 Jul 19;181(1):153-7. doi: 10.1016/j.bbr.2007.03.028. Epub 2007 Mar 31.
This experiment aimed to examine the role of the CB1 and Opioid mu receptors on fat preference by administering the CB1 inverse agonist AM 251 (5mg/kg i.p.) and the opioid mu antagonist beta-Funaltrexamine (15mg/kg s.c.) for 4 days to fat-preferring C57BL/6 mice fed a two-choice high-fat/low-fat diet. Both drugs were found to significantly reduce total energy intake, high-fat diet intake and fat preference during treatment.
本实验旨在通过对偏好脂肪的C57BL/6小鼠给予CB1反向激动剂AM 251（5毫克/千克，腹腔注射）和阿片μ受体拮抗剂β-氟纳曲胺（15毫克/千克，皮下注射）4天，来研究CB1和阿片μ受体在脂肪偏好中的作用。结果发现，两种药物在治疗期间均能显著降低总能量摄入、高脂饮食摄入量和脂肪偏好。
