Hyland Niall P, Pittman Quentin J, Sharkey Keith A
Institute of Infection, Immunity and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alta., Canada.
Peptides. 2007 Jun;28(6):1185-90. doi: 10.1016/j.peptides.2007.03.011. Epub 2007 Mar 30.
Peptide YY (PYY) is a gastrointestinal hormone, localized in enteroendocrine L-cells. Its hydrolyzed form PYY(3-36) is a satiety factor. The aim of this study was to identify if intestinal PYY enteroendocrine cells or content correlate with the diet-induced obese (DIO) or diet-resistant (DR) phenotypes. We also examined intestinal sensitivity to PYY and PYY(3-36) in DIO and DR rats. Animals were maintained on a medium-high fat diet and split into DIO and DR groups based on weight gain. PYY immunoreactive cells were unaltered in DIO intestine and stomach compared to DR rats. PYY content and circulating levels were also unchanged in DIO rats. Intestinal PYY and PYY(3-36) responses were enhanced in fasted rats, and equipotent in both DIO and DR jejunum. We conclude that PYY cell number, tissue content and peripheral sensitivity are maintained in DIO rats. Our data suggests that neither PYY nor PYY(3-36) contribute to the maintenance of either the DIO or DR phenotype, and that peripheral resistance to PYY and PYY(3-36) does not accompany DIO.
肽YY（PYY）是一种胃肠激素，定位于肠内分泌L细胞。其水解形式PYY（3-36）是一种饱腹感因子。本研究的目的是确定肠道PYY肠内分泌细胞或其含量是否与饮食诱导的肥胖（DIO）或饮食抵抗（DR）表型相关。我们还检测了DIO和DR大鼠肠道对PYY和PYY（3-36）的敏感性。动物维持在中高脂肪饮食，并根据体重增加分为DIO组和DR组。与DR大鼠相比，DIO大鼠肠道和胃中的PYY免疫反应性细胞未发生改变。DIO大鼠的PYY含量和循环水平也未改变。禁食大鼠的肠道PYY和PYY（3-36）反应增强，且在DIO和DR空肠中效力相当。我们得出结论，DIO大鼠的PYY细胞数量、组织含量和外周敏感性得以维持。我们的数据表明，PYY和PYY（3-36）均不参与DIO或DR表型的维持，并且DIO不伴有对PYY和PYY（3-36）的外周抵抗。
