Liu Chun-Jen, Kao Jia-Horng
Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, R.O.C.
J Chin Med Assoc. 2007 Apr;70(4):141-5. doi: 10.1016/S1726-4901(09)70346-6.
Chronic hepatitis B virus (HBV) infection is the primary risk factor for the development of hepatocellular carcinoma worldwide. After decades of chronic hepatitis, about 30-40% of patients progress into liver cirrhosis, and of them, around 1-5% subsequently develop hepatocellular carcinoma (HCC) annually. Since the carcinogenic process involves the interplay between the hepatitis virus and the host hepatocytes, both genomes contribute to the final pathogenic outcome, either individually or synergistically. Studying the genetic factors predisposing hepatocarcinogenesis in both host and viral genomes will help illuminate the critical carcinogenic mechanisms, and create molecular targets for future therapy. In this article, we thus review the epidemiology of HBV-related HCC and viral factors involved in hepatocarcinogenesis.
慢性乙型肝炎病毒（HBV）感染是全球肝细胞癌发生的主要危险因素。经过数十年的慢性肝炎，约30%-40%的患者会进展为肝硬化，其中每年约有1%-5%的患者随后会发展为肝细胞癌（HCC）。由于致癌过程涉及肝炎病毒与宿主肝细胞之间的相互作用，两个基因组都会单独或协同地对最终的致病结果产生影响。研究宿主和病毒基因组中易导致肝癌发生的遗传因素，将有助于阐明关键的致癌机制，并为未来的治疗创造分子靶点。因此，在本文中，我们综述了HBV相关HCC的流行病学以及参与肝癌发生的病毒因素。
