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[环磷酸腺苷对艾氏腹水癌细胞有丝分裂周期的同步化作用]

[The synchronizing effect of cyclic 3',5'-adenosine monophosphate on the mitotic cycle of Ehrlich ascitic carcinoma cells].

作者信息

Volkov I N

出版信息

Biull Eksp Biol Med. 1976 Jan;81(1):66-8.

PMID:174763
Abstract

A study was made of the number of mitoses and of the DNA-synthesizing cells in the ascitic Ehrlich carcinoma in the course of 24 hours after the injection of cyclic 3',5'-adenosinmonophosphate to mice. It was found that as the result of the preprrophase inhibition and, possibly, of stimulation of the cell entry into the S-phase, 8 hours after the action a great number of cells began to divide almost simultaneously. The effect of mitosis synchronization was assessed in the tumour cell population.

摘要

对注射环磷腺苷后24小时内小鼠腹水型艾氏癌中的有丝分裂数量和DNA合成细胞进行了研究。结果发现,由于前期抑制以及可能对细胞进入S期的刺激作用,在作用8小时后,大量细胞几乎同时开始分裂。在肿瘤细胞群体中评估了有丝分裂同步化的效果。

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