Matsak N Ia, Romanov N Ia, Antokhin A I
Biull Eksp Biol Med. 1987 Jan;103(1):89-92.
Chalone-containing preparation has been obtained from ascitic Ehrlich's tumour by alcohol precipitation and the effect of various preparation doses on mitotic activity and DNA synthesis in the tumour has been studied. The preparation was shown to suppress tumour cell proliferation, acting on mitosis initiation and mitotic S phase as well as on DNA synthesis in the cells at S phase of mitotic cycle. The effect of the preparation on DNA synthesis in phase S cells was more pronounced than on cells entering DNA synthesis phase. The changes in all the parameters examined were dose-dependent. The preparation effect was tissue-specific.
通过酒精沉淀法从腹水型艾氏瘤中获得了含抑素制剂，并研究了不同剂量该制剂对肿瘤有丝分裂活性和DNA合成的影响。结果表明，该制剂可抑制肿瘤细胞增殖，作用于有丝分裂起始期、有丝分裂S期以及有丝分裂周期S期细胞中的DNA合成。该制剂对S期细胞DNA合成的影响比对进入DNA合成期细胞的影响更为显著。所有检测参数的变化均呈剂量依赖性。该制剂的作用具有组织特异性。
