双相情感障碍患者杏仁核外侧核中的神经元胞体大小减小。
Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder.
作者信息
Bezchlibnyk Yarema B, Sun Xiujun, Wang Jun-Feng, MacQueen Glenda M, McEwen Bruce S, Young L Trevor
机构信息
The Vivian Rakoff Mood Disorders Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
出版信息
J Psychiatry Neurosci. 2007 May;32(3):203-10.
Abstract
OBJECTIVE
Morphometric studies of postmortem brains from subjects with mood disorders have reported altered density of glial cells in the amygdala; however, the nuclear regions have not been examined individually.
METHODS
We assessed the size and density of both neuronal and glial cells in discrete amygdalar nuclei in postmortem sections from subjects with major depressive disorder, bipolar disorder (BD) and schizophrenia and from nonpsychiatric control subjects. Three adjacent Nissl-stained sections were examined from each individual.
RESULTS
We report significantly decreased neuron somal size in the lateral amygdalar nucleus (LAN) and the accessory basal parvocellular nucleus (ABPC) in subjects with BD, relative to control subjects. These changes in cellular morphology were most prominent in the LAN in sections obtained from the left hemisphere.
CONCLUSIONS
These findings add to increasing evidence for neuropathological changes in the amygdala of subjects with BD and specifically implicate the LAN and ABPC in this disorder.
摘要
目的
对患有情绪障碍的受试者的死后大脑进行形态计量学研究报告称，杏仁核中的神经胶质细胞密度发生了改变；然而，尚未对各个核区域进行单独检查。
方法
我们评估了患有重度抑郁症、双相情感障碍（BD）和精神分裂症的受试者以及非精神科对照受试者的死后切片中离散杏仁核核团中神经元和神经胶质细胞的大小和密度。从每个个体检查三张相邻的尼氏染色切片。
结果
我们报告称，与对照受试者相比，患有双相情感障碍的受试者的外侧杏仁核核团（LAN）和副基底小细胞核（ABPC）中的神经元胞体大小显著减小。这些细胞形态变化在从左半球获得的切片中的LAN中最为明显。
结论
这些发现进一步证明了双相情感障碍患者杏仁核存在神经病理学变化的证据，并特别表明LAN和ABPC与这种疾病有关。
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