Fouque Denis, Guebre-Egziabher Fitsum
Department of Nephrology and Centre de Recherche en Nutrition Humaine, Edouard Herriot Hospital, 69437 Lyon Cedex 03, France.
Int Urol Nephrol. 2007;39(1):239-46. doi: 10.1007/s11255-006-9108-3. Epub 2006 Nov 24.
The prevalence of malnutrition in the course of chronic kidney disease has not changed recently and is still between 30 and 50%. About 10% of patients on maintenance dialysis show signs of severe malnutrition. Recent progress has been made on protein metabolism, the validation of new diagnostic tools, and the use of anabolic compounds. Large clinical trials have characterized the use of medications for renutrition, and international guidelines are currently updated. Neverthless, physicians will be mostly efficient at the stage of malnutrition prevention, by implementing an early, interactive dietary and nutritional care programs in close collaboration with specialized dietitians.
慢性肾脏病病程中营养不良的患病率近期并无变化，仍在30%至50%之间。约10%的维持性透析患者有严重营养不良的迹象。在蛋白质代谢、新诊断工具的验证以及合成代谢化合物的使用方面取得了新进展。大型临床试验已对营养恢复用药的使用进行了特征描述，国际指南目前正在更新。尽管如此，医生若能与专业营养师密切合作，实施早期、互动式的饮食和营养护理计划，在营养不良预防阶段将最为有效。
