短促肾上腺皮质激素试验在评估下丘脑 - 垂体 - 肾上腺皮质功能中的应用
Short ACTH test in assessing hypothalamic-pituitary-adrenocortical function.
作者信息
Kehlet H, Blichert-Toft M, Lindholm J, Rasmussen P
出版信息
Br Med J. 1976 Jan 31;1(6004):249-51. doi: 10.1136/bmj.1.6004.249.
Abstract
The adrenocortical response to the simple 30-minute ACTH stimulation test was compared with the hypothalamic-pituitary-adrenocortical (HPA) response to insulin-induced hypoglycaemia in 25 patients with various degrees of hypothalamic-pituitary malfunction. The correlations between the increase in plasma cortisol during insulin hypoglycaemia and that during ACTH stimulation (r = 0-66) and between peak plasma cortisol levels during the two tests (r = 0-90) were highly significant. Peak plasma cortisol levels in individual patients were similar on both tests, no patient showing any major discrepancy between the two test results. Thus the simple 30-minute ACTH stimulation test seems to be reliable in detecting imparied HPA function.
摘要
在25例患有不同程度下丘脑 - 垂体功能障碍的患者中，将肾上腺皮质对简单的30分钟促肾上腺皮质激素（ACTH）刺激试验的反应与下丘脑 - 垂体 - 肾上腺皮质（HPA）对胰岛素诱导的低血糖的反应进行了比较。胰岛素低血糖期间血浆皮质醇的增加与ACTH刺激期间血浆皮质醇的增加之间的相关性（r = 0 - 66）以及两次试验期间血浆皮质醇峰值水平之间的相关性（r = 0 - 90）非常显著。个体患者在两次试验中的血浆皮质醇峰值水平相似，没有患者在两次试验结果之间显示出任何重大差异。因此，简单的30分钟ACTH刺激试验在检测受损的HPA功能方面似乎是可靠的。
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