Mika Renée, Morgan Bruce, Cron Michael, Lotoczky Josh, Pole John
Michigan College of Optometry, Ferris State University, Big Rapids, Michigan 49307, USA.
Optometry. 2007 May;78(5):225-31. doi: 10.1016/j.optm.2006.12.013.
This prospective case series was conducted to describe the safety and efficacy of orthokeratology with the Emerald Contact Lens for Overnight Orthokeratology (Oprifocon A; Euclid Systems Corporation, Herndon, Virginia) among young myopes.
Twenty subjects (ages 10 to 16) were enrolled in the 6-month pilot study. Subjects were fit empirically with overnight orthokeratology lenses and evaluated at 1 day, 1 week, 1 month, 2 months, 3 months, and 6 months.
Sixteen subjects completed the study. The mean baseline spherical equivalent refraction (SER) was -2.06 diopters (D) (+/-0.75). The mean SER at 6 months was -0.16 D (+/-0.38). The mean baseline uncorrected acuity was 0.78 (+/-0.28) logarithmic minimum angle of resolution (logMAR) equivalent (20/100 Snellen). The mean logMAR equivalent at 6 months was -0.03 +/- 0.12 (<20/20 Snellen). On average, 40% of eyes showed some type of corneal staining between the 1-week and 6-month visits. No serious adverse events occurred during the study.
In contrast to previously published studies that reported maximum results at 2 weeks, subjects reached maximum reduction in myopia at the 1-week visit and, on average, obtained a 92.2% reduction in spherical equivalent refractive error at 6 months. This pilot study lends to a growing body of evidence that short-term correction of mild to moderate myopia with overnight orthokeratology is safe and efficacious in children and adolescents.
本前瞻性病例系列研究旨在描述使用欧几里得系统公司（位于弗吉尼亚州赫恩登）的用于夜间角膜塑形术的翡翠隐形眼镜（oprifocon A）对年轻近视患者进行角膜塑形术的安全性和有效性。
20名年龄在10至16岁的受试者参加了这项为期6个月的试点研究。受试者根据经验佩戴夜间角膜塑形术镜片，并在第1天、第1周、第1个月、第2个月、第3个月和第6个月进行评估。
16名受试者完成了研究。平均基线等效球镜度（SER）为-2.06屈光度（D）（±0.75）。6个月时的平均SER为-0.16 D（±0.38）。平均基线未矫正视力为0.78（±0.28）对数最小分辨角（logMAR）等效值（20/100 Snellen）。6个月时的平均logMAR等效值为-0.03±0.12（<20/20 Snellen）。平均而言，在第1周和第6个月的随访之间，40%的眼睛出现了某种类型的角膜染色。研究期间未发生严重不良事件。
与之前发表的报告在2周时取得最大效果的研究不同，受试者在第1周的随访时近视度数降低到最大，平均而言，在6个月时等效球镜屈光不正降低了92.2%。这项试点研究为越来越多的证据提供了支持，即夜间角膜塑形术对儿童和青少年轻度至中度近视的短期矫正安全有效。
