Jakobsen M U, Berentzen T, Sørensen T I A, Overvad K
Institute of Preventive Medicine, Centre for Health And Society, Copenhagen University Hospital, Copenhagen, Denmark.
Epidemiol Rev. 2007;29:77-87. doi: 10.1093/epirev/mxm002. Epub 2007 May 2.
It has been hypothesized that visceral fat releases free fatty acids and adipokines and thereby exposes the liver to fat accumulation. The authors aimed to evaluate current epidemiologic evidence for an association between abdominal fat and liver fat content. Clinical and epidemiologic studies with data on abdominal fat and liver fat content were reviewed. Studies using waist circumference to estimate abdominal fat mass suggested a direct association between abdominal fat and liver fat content. Studies using imaging methods suggested a direct association between intraabdominal fat and liver fat content, but not between subcutaneous abdominal fat and liver fat content. In conclusion, clinical and epidemiologic studies of abdominal fat and liver fat content suggest a direct association between abdominal fat and liver fat content which is probably accounted for by visceral fat. However, results from the included studies do not allow strong conclusions regarding the temporal sequence of events. Future longitudinal studies are recommended to obtain additional information on associations and mechanisms. Both abdominal fat depots and other body compartments of interest should be included to further investigate the association between specific fat depots and liver fat content. Biomarkers may provide insight into underlying mechanisms.
有假说认为，内脏脂肪会释放游离脂肪酸和脂肪因子，从而使肝脏出现脂肪堆积。作者旨在评估目前关于腹部脂肪与肝脏脂肪含量之间关联的流行病学证据。对有腹部脂肪和肝脏脂肪含量数据的临床和流行病学研究进行了综述。使用腰围来估计腹部脂肪量的研究表明，腹部脂肪与肝脏脂肪含量之间存在直接关联。使用成像方法的研究表明，腹内脂肪与肝脏脂肪含量之间存在直接关联，但皮下腹部脂肪与肝脏脂肪含量之间不存在直接关联。总之，关于腹部脂肪与肝脏脂肪含量的临床和流行病学研究表明，腹部脂肪与肝脏脂肪含量之间存在直接关联，这可能是由内脏脂肪导致的。然而，纳入研究的结果无法就事件的时间顺序得出有力结论。建议未来进行纵向研究，以获取有关关联和机制的更多信息。应纳入腹部脂肪库和其他感兴趣的身体部位，以进一步研究特定脂肪库与肝脏脂肪含量之间的关联。生物标志物可能有助于深入了解潜在机制。
