Molnar Miklos Zsolt, Szentkiralyi Andras, Lindner Anett, Czira Maria Eszter, Szabo Andras, Mucsi Istvan, Novak Marta
Institute of Behavioral Sciences, 1st Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Room 1913, 19th floor, 4 Nagyvarad ter, Budapest, H-1089, Hungary.
Nephrol Dial Transplant. 2007 Sep;22(9):2686-92. doi: 10.1093/ndt/gfm246. Epub 2007 May 3.
Obstructive sleep apnoea syndrome (OSAS) is much more prevalent in patients on dialysis than in the general population. Our aim was to assess for the first time the prevalence of patients with a high risk for OSAS and its clinical correlates in a large sample of kidney transplanted patients. We also wanted to compare the prevalence of the disorder between waitlisted dialysis patients (WL) and kidney transplanted patients (Tx).
One thousand sixty-seven kidney transplanted patients were asked to participate in a cross-sectional survey ('TransQoL-HU Study'). Socio-demographic data, history of renal disease, medication, comorbidity and laboratory parameters were collected at enrolment. Patients completed a battery of self-administered questionnaires including the Berlin Sleep Apnoea Questionnaire to assess risk status of OSAS.
The final analyses included 841 Tx and 175 WL patients. The prevalence of high risk for OSAS was similar in the transplanted group vs WL patients (27% vs 33%). In multivariate logistic regression analysis male gender, older age, lower educational status, worse kidney function, use of hypnotic drugs and comorbidity were independent predictors for high risk of OSAS in kidney transplanted patients.
High risk for sleep apnoea is highly prevalent in the kidney transplanted population. In addition to the well-known risk factors of OSAS (male gender, obesity, use of hypnotic drugs, comorbidity), impaired kidney function was also independently associated with high risk for OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）在透析患者中的患病率远高于普通人群。我们的目的是首次评估大量肾移植患者中OSAS高危患者的患病率及其临床相关性。我们还想比较等待透析患者（WL）和肾移植患者（Tx）之间该疾病的患病率。
1667名肾移植患者被邀请参加一项横断面调查（“TransQoL-HU研究”）。在入组时收集社会人口统计学数据、肾脏疾病史、用药情况、合并症和实验室参数。患者完成一系列自我管理的问卷，包括柏林睡眠呼吸暂停问卷，以评估OSAS的风险状况。
最终分析纳入了841名Tx患者和175名WL患者。移植组与WL患者中OSAS高危的患病率相似（分别为27%和33%）。在多因素逻辑回归分析中，男性、年龄较大、教育程度较低、肾功能较差、使用催眠药物和合并症是肾移植患者OSAS高危的独立预测因素。
睡眠呼吸暂停高危在肾移植人群中非常普遍。除了OSAS的众所周知的危险因素（男性、肥胖、使用催眠药物、合并症）外，肾功能受损也与OSAS高危独立相关。
