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强直性脊柱炎患者中阻塞性睡眠呼吸暂停综合征的患病率。

The prevalence of obstructive sleep apnoea syndrome in ankylosing spondylitis patients.

作者信息

Solak Ozlem, Fidan Fatma, Dündar Umit, Türel Aycan, Ayçiçek Abdullah, Kavuncu Vural, Unlü Mehmet

机构信息

1Department of Physical Medicine and Rehabilitation, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey.

出版信息

Rheumatology (Oxford). 2009 Apr;48(4):433-5. doi: 10.1093/rheumatology/kep021. Epub 2009 Feb 17.

Abstract

OBJECTIVE

To assess the prevalence of obstructive sleep apnoea syndrome (OSAS) in AS patients.

METHODS

Thirty-one patients with AS were included in the study. The demographic data, spinal mobility measures and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were recorded for each patient. All participants underwent one night of sleep recording, which was performed using a polysomnography (PSG). Pulmonary function test (PFT) was performed for all subjects and symptoms of OSAS were questioned.

RESULTS

Seven (22.6%) of 31 AS patients had OSAS according to PSG assessments. The mean BMI, disease duration, BASDAI score, neck circumference and occiput-wall distance were higher in patients with OSAS, but the differences were not significant. The mean ages of patients with OSAS were significantly higher than the patients without OSAS. The prevalence of OSAS in patients under the age of 35 years was found to be 6.3%, whereas the prevalence of OSAS in patients at the age of 35 years or over was 40.0% (P = 0.037). The prevalence of OSAS in AS patients with a disease duration <5 years was 11.8% and its prevalence in AS patients with a disease duration of >or=5 years was 35.7% (P = 0.198). PFT was restrictive in 16 (53.3%) patients and obstructive in none.

CONCLUSIONS

The prevalence of OSAS in AS patients is higher than reported in the general population. The diagnosis of OSAS should be kept in mind and OSAS symptoms should be considered especially in AS patients at the age of >or=35 years and in AS patients with a disease duration of >or=5 years.

摘要

目的

评估强直性脊柱炎(AS)患者中阻塞性睡眠呼吸暂停综合征(OSAS)的患病率。

方法

31例AS患者纳入本研究。记录每位患者的人口统计学数据、脊柱活动度测量值及巴斯强直性脊柱炎疾病活动指数(BASDAI)评分。所有参与者均接受一晚的睡眠记录,采用多导睡眠图(PSG)进行。对所有受试者进行肺功能测试(PFT)并询问OSAS症状。

结果

根据PSG评估,31例AS患者中有7例(22.6%)患有OSAS。OSAS患者的平均体重指数、病程、BASDAI评分、颈围和枕墙距较高,但差异无统计学意义。OSAS患者的平均年龄显著高于无OSAS患者。35岁以下患者中OSAS的患病率为6.3%,而35岁及以上患者中OSAS的患病率为40.0%(P = 0.037)。病程<5年的AS患者中OSAS的患病率为11.8%,病程≥5年的AS患者中OSAS的患病率为35.7%(P = 0.198)。16例(53.3%)患者的PFT为限制性通气障碍,无阻塞性通气障碍。

结论

AS患者中OSAS的患病率高于普通人群。应牢记OSAS的诊断,尤其对于年龄≥35岁及病程≥5年的AS患者,应考虑OSAS症状。

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