Ukiya Motohiko, Akihisa Toshihiro, Tokuda Harukuni, Koike Kazuo, Kimura Yumiko, Asano Takeshi, Motohashi Shigeyasu, Nikaido Tamotsu, Nishino Hoyoku
College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
J Nat Prod. 2003 Nov;66(11):1476-9. doi: 10.1021/np030276v.
Six new rearranged 3,4-seco-tirucallane-type triterpenoids (1-6) have been isolated from the diethyl ether extract of the pollen grains of sunflower (Helianthus annuus). These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. All of the compounds tested showed potent inhibitory effects on EBV-EA activation (97-100% inhibition at 1 x 10(3) mol ratio/TPA).
从向日葵（Helianthus annuus）花粉粒的乙醚提取物中分离出六种新的重排3,4-裂环-四环三萜类化合物（1-6）。对这些化合物在Raji细胞中对肿瘤启动子12-O-十四酰佛波醇13-乙酸酯（TPA）诱导的爱泼斯坦-巴尔病毒早期抗原（EBV-EA）诱导的抑制作用进行了评估。所有测试的化合物对EBV-EA激活均显示出强效抑制作用（在1×10⁻³摩尔比/TPA时抑制率为97-100%）。
