桦褐孔菌中具有抗炎作用的羊毛甾烷型三萜酸。
Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus.
作者信息
Kamo Tsunashi, Asanoma Masashi, Shibata Hisao, Hirota Mitsuru
机构信息
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan.
出版信息
J Nat Prod. 2003 Aug;66(8):1104-6. doi: 10.1021/np0300479.
Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12 alpha,28-dihydroxy-3 alpha-(3'-hydroxy-3'-methylglutaryloxy)-24-methyllanosta-8,24(31)-dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema on mouse ears by 49-86% with a 400 nmol/ear application.
从桦剥管孔菌子实体中分离出六种羊毛甾烷型三萜酸。它们被鉴定为多孔酸A（1）和C（2）、多孔酸A的三种衍生物（3 - 5）以及一种新化合物，（+）-12α，28 - 二羟基 - 3α -（3'-羟基 - 3'-甲基戊二酰氧基）-24 - 甲基羊毛甾 - 8，24（31）-二烯 - 26 - 酸（6）。所有这些化合物以400 nmol/耳的剂量涂抹时，对12 - O - 十四酰佛波醇 - 13 - 乙酸酯（TPA）诱导的小鼠耳部水肿的抑制率为49 - 86%。
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