Saito T R, Aoki S, Shutoh Y, Hokao R, Sasaki Y, Amao H, Wakafuji Y, Sugiyama M, Takahashi K W
Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Jikken Dobutsu. 1991 Oct;40(4):561-3. doi: 10.1538/expanim1978.40.4_561.
The ejaculatory response induced by p-chloroamphetamine (PCA) in male rats, hamsters and mice was observed during 2 hours after the injection. The animals were treated intraperitoneally with PCA at doses ranging from 0.78125 to 160 mg/kg. The ED50 (effective dose in 50% of animals) values of PCA for the initiation of ejaculation in rats and hamsters were 1.3397 (1.0732-1.6725) and 0.1105 (0.0802-0.1522) mg/kg, respectively. On the other hand, no ejaculation was observed in any mice at any doses examined. So we concluded that there are species differences in the ejaculatory response, induced by PCA, among rats, hamsters and mice.
在注射后2小时内观察了对氯苯丙胺（PCA）诱导的雄性大鼠、仓鼠和小鼠的射精反应。动物腹腔注射PCA，剂量范围为0.78125至160mg/kg。PCA在大鼠和仓鼠中引发射精的ED50（50%动物的有效剂量）值分别为1.3397（1.0732 - 1.6725）和0.1105（0.0802 - 0.1522）mg/kg。另一方面，在所检查的任何剂量下，未在任何小鼠中观察到射精。因此，我们得出结论，PCA诱导的射精反应在大鼠、仓鼠和小鼠之间存在物种差异。
