Humphries C R, O'Brien M, Paxinos G
Pharmacol Biochem Behav. 1980 Jun;12(6):851-4. doi: 10.1016/0091-3057(80)90443-8.
The short term monoamine releaser p-chloroamphetamine (PCA) was injected intraperitoneally in male rats housed at 20 degrees C. Within 2 hr of PCA injections (2.5, 5.0, 8.0 or 10.0 mg/kg), rats showed ejaculation, decreased colonic temperature, increased salivation, and increased irritability. Ejaculation and salivation scores were considerably lower in the 2.5 mg/kg than in the higher dose groups, but otherwise were not dose dependent at the doses used. Hypothermia was of similar magnitude in all groups, but lasted longer in the higher dose groups. Irritability increased with dose size. In order to study the role of ambient temperature in PCA-induced behavioral changes, observations were made on an additional group or rats housed at the higher ambient temperature of 25 degrees C. In these rats an increase, rather than a decrease, in mean colonic temperature was observed following PCA injection (5 mg/kg). Ejaculation and irritability scores were similar to those observed at the lower ambient temperature, but salivation was enhanced. It is suggested that PCA induces ejaculation, salivation, irritability and, depending on the ambient temperature, either hypothermia or hyperthermia.
将短期单胺释放剂对氯苯丙胺（PCA）腹腔注射到饲养在20摄氏度环境中的雄性大鼠体内。在注射PCA（2.5、5.0、8.0或10.0毫克/千克）后的2小时内，大鼠出现射精、结肠温度降低、唾液分泌增加和易怒。2.5毫克/千克剂量组的射精和唾液分泌评分明显低于高剂量组，但在所使用的剂量下，其他方面不存在剂量依赖性。所有组的体温过低程度相似，但在高剂量组持续时间更长。易怒程度随剂量增加而增加。为了研究环境温度在PCA诱导的行为变化中的作用，对饲养在25摄氏度较高环境温度下的另一组大鼠进行了观察。在这些大鼠中，注射PCA（5毫克/千克）后观察到结肠平均温度升高，而不是降低。射精和易怒评分与在较低环境温度下观察到的相似，但唾液分泌增强。提示PCA可诱导射精、唾液分泌、易怒，并且根据环境温度的不同，可导致体温过低或体温过高。
