Bánhegyi Gábor, Baumeister Peter, Benedetti Angelo, Dong Dezheng, Fu Yong, Lee Amy S, Li Jianze, Mao Changhui, Margittai Eva, Ni Min, Paschen Wulf, Piccirella Simona, Senesi Silvia, Sitia Roberto, Wang Miao, Yang Wei
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Puskin utca 9, 1088, Budapest, Hungary.
Ann N Y Acad Sci. 2007 Oct;1113:58-71. doi: 10.1196/annals.1391.007. Epub 2007 May 4.
Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress-sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.
应激是体内稳态的失衡，即使在亚细胞水平也能被感知。包括内质网（ER）在内的各种细胞器的应激感知能力已被描述。很明显，急性或持续性内质网应激在许多人类疾病中起重要作用；尤其是那些涉及专门进行蛋白质分泌的器官/组织的疾病。本文总结了内质网应激在多种人类病理生理状况中的新作用，如致癌作用和肿瘤进展、脑缺血、浆细胞成熟和凋亡、肥胖、胰岛素抵抗以及2型糖尿病。内质网应激反应机制的某些成分被确定为疾病的生物标志物或治疗干预的可能靶点。
