Jia Tong-Tong, Zhang Yuanyuan, Hou Ji-Ting, Niu Huawei, Wang Shan
College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, China.
College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
Front Chem. 2023 Jan 27;11:1126309. doi: 10.3389/fchem.2023.1126309. eCollection 2023.
Hydrogen sulfide (HS), as an important endogenous signaling molecule, plays a vital role in many physiological processes. The abnormal behaviors of hydrogen sulfide in organisms may lead to various pathophysiological processes. Monitoring the changes in hydrogen sulfide is helpful for pre-warning and treating these pathophysiological processes. Fluorescence imaging techniques can be used to observe changes in the concentration of analytes in organisms in real-time. Therefore, employing fluorescent probes imaging to investigate the behaviors of hydrogen sulfide in pathophysiological processes is vital. This paper reviews the design strategy and sensing mechanisms of hydrogen sulfide-based fluorescent probes, focusing on imaging applications in various pathophysiological processes, including neurodegenerative diseases, inflammation, apoptosis, oxidative stress, organ injury, and diabetes. This review not only demonstrates the specific value of hydrogen sulfide fluorescent probes in preclinical studies but also illuminates the potential application in clinical diagnostics.
硫化氢（HS）作为一种重要的内源性信号分子，在许多生理过程中发挥着至关重要的作用。生物体中硫化氢的异常行为可能导致各种病理生理过程。监测硫化氢的变化有助于对这些病理生理过程进行预警和治疗。荧光成像技术可用于实时观察生物体内分析物浓度的变化。因此，利用荧光探针成像来研究硫化氢在病理生理过程中的行为至关重要。本文综述了基于硫化氢的荧光探针的设计策略和传感机制，重点介绍了其在各种病理生理过程中的成像应用，包括神经退行性疾病、炎症、细胞凋亡、氧化应激、器官损伤和糖尿病。这篇综述不仅展示了硫化氢荧光探针在临床前研究中的特定价值，还阐明了其在临床诊断中的潜在应用。
