Yokoyama Yoshiro, Oyane Ayako, Ito Atsuo
Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1, Higashi, Tsukuba-Shi, Ibaraki, Japan.
J Mater Sci Mater Med. 2007 Sep;18(9):1727-34. doi: 10.1007/s10856-007-3024-7. Epub 2007 May 5.
A biodegradable polymer coated with a bonelike apatite layer on its surface would be useful as a scaffold for bone tissue regeneration. In this study, poly(L-lactic acid) (PLLA) was treated with oxygen plasma to produce oxygen-containing functional groups on its surface. The plasma-treated specimen was then alternately dipped in aqueous CaCl(2) and K(2)HPO(4).3H(2)O solutions three times, to deposit apatite precursors onto the surface. The surface-modified specimen then successfully formed a dense and uniform bonelike surface apatite layer after immersion for 24 h in a simulated body fluid with ion concentrations approximately equal to those of human blood plasma. The adhesive strength between the apatite layer and the specimen surface increased as the power density of the oxygen plasma used increased. The maximum adhesive strength of the apatite layer to the specimen was significantly higher than that to the commercially available artificial bone, HAPEX. The resultant bonelike apatite-PLLA composite would be useful as a scaffold for bone tissue regeneration.
一种表面涂有类骨磷灰石层的可生物降解聚合物可作为骨组织再生的支架。在本研究中，聚（L-乳酸）（PLLA）经氧等离子体处理以在其表面产生含氧官能团。然后将经等离子体处理的样品交替浸入氯化钙水溶液和磷酸氢二钾·3H₂O溶液中三次，以在表面沉积磷灰石前体。然后，将表面改性的样品在离子浓度近似于人类血浆的模拟体液中浸泡24小时后，成功形成了致密且均匀的类骨表面磷灰石层。随着所用氧等离子体功率密度的增加，磷灰石层与样品表面之间的粘附强度增大。磷灰石层与样品的最大粘附强度显著高于与市售人造骨HAPEX的粘附强度。所得的类骨磷灰石-PLLA复合材料可作为骨组织再生的支架。
