Hong Xiumei, Niu Tianhua, Chen Changzhong, Wang Binyan, Venners Scott A, Fang Zhian, Xu Xiping
Center for Population Genetics, Division of Epidemiology and Biostatistics, School of Public Health M/C 923, University of Illinois at Chicago, 1603 W Taylor, Rm 978B, Chicago, IL 60612, USA.
Eur J Epidemiol. 2007;22(5):335-41. doi: 10.1007/s10654-007-9117-2. Epub 2007 May 5.
Osteoporosis is a major public health concern and its prevalence can be predicted based on forearm bone mineral density (BMD). This study is to investigate the familial aggregation of forearm BMD in a population-based, cross-sectional study in Anhui, China. Information on sociodemographic and environmental variables was obtained from 1,636 subjects from 409 nuclear families (including mother, father, and their first two children) by a standardized questionnaire. The forearm BMD was measured by peripheral dual-energy X-ray absorptiometry (pDXA). Using generalized additive models with a sequential adjustment for covariates, it was clearly indicated that the forearm BMD of the mother, the father, and the first sibling each had a significant and independent relation to the forearm BMD of the second sibling. Furthermore, using multiple logistic regression, the second sibling had an odds ratio (OR) of 5.3 (95%CI: 2.0-14.5) of having an extremely low (bottom 10th percentile) proximal forearm BMD and an OR of 4.3 (95%CI: 1.6-12.0) of having an extremely low distal forearm BMD when the parental mean forearm BMD was low and the first sibling's forearm BMD was low. Our findings showing strong familial aggregation of both proximal and distal forearm BMD values suggest that genetic factors play a significant role in determining both traits.
骨质疏松症是一个重大的公共卫生问题，其患病率可根据前臂骨密度（BMD）进行预测。本研究旨在通过一项基于人群的横断面研究，调查中国安徽人群中前臂骨密度的家族聚集性。通过标准化问卷从409个核心家庭（包括母亲、父亲及其头两个孩子）的1636名受试者中获取社会人口统计学和环境变量信息。采用外周双能X线吸收法（pDXA）测量前臂骨密度。使用广义相加模型并对协变量进行序贯调整，结果清楚地表明，母亲、父亲和第一个兄弟姐妹的前臂骨密度与第二个兄弟姐妹的前臂骨密度均存在显著且独立的关系。此外，使用多元逻辑回归分析发现，当父母的平均前臂骨密度较低且第一个兄弟姐妹的前臂骨密度较低时，第二个兄弟姐妹近端前臂骨密度极低（最低十分位数）的比值比（OR）为5.3（95%可信区间：2.0 - 14.5），远端前臂骨密度极低的OR为4.3（95%可信区间：1.6 - 12.0）。我们的研究结果显示近端和远端前臂骨密度值均存在强烈的家族聚集性，这表明遗传因素在决定这两个性状方面发挥着重要作用。
