Feng Yan, Hsu Yi-Hsiang, Terwedow Henry, Chen Chang zhong, Xu Xin, Niu Tianhua, Zang Tonghua, Wu Di, Tang Genfu, Li Zhiping, Hong Xiumei, Wang Binyan, Brain Joseph D, Cummings Steven R, Rosen Clifford, Bouxsein Mary L, Xu Xiping
Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA.
Osteoporos Int. 2005 Dec;16(12):1917-23. doi: 10.1007/s00198-005-1962-9. Epub 2005 Sep 15.
Familial aggregation of bone mineral density (BMD) and bone mineral content (BMC) has been shown in twin and familial studies, but most sample sizes were small. We here report a large familial aggregation study in a Chinese population. A total of 13,973 siblings aged 25-64 years from 3,882 families were enrolled from Anhui, China. We assessed the whole-body, hip and lumbar spine BMD and BMC by dual-energy X-ray absorptiometry (DXA). Intra-class correlation coefficients of BMD and BMC between siblings varied among different skeletal sites and between different age groups of male sib-pairs and premenopausal and postmenopausal female sib-pairs, with a range of 0.228 to 0.397. The sibling recurrence risk ratio (lambdas) of osteoporosis was 2.6 in our population. We also evaluated the joint association of the BMD values of the first siblings and the second siblings with the risk of low BMD (defined as less than the 10th percentile of the same group population) of their younger siblings. If both the first and second siblings' BMDs were in the lowest tertile, the odd ratios (ORs) of low BMD in their subsequent siblings were 8.32 [95% confidence interval (CI) 5.59-12.39)], 8.71 (95% CI 5.74-13.22) and 5.90 (95% CI 3.57-9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults.
双胞胎和家族研究已表明骨密度（BMD）和骨矿物质含量（BMC）存在家族聚集性，但大多数样本量较小。我们在此报告一项针对中国人群的大型家族聚集性研究。从中国安徽招募了来自3882个家庭的13973名年龄在25至64岁之间的兄弟姐妹。我们通过双能X线吸收法（DXA）评估全身、髋部和腰椎的BMD和BMC。兄弟姐妹之间BMD和BMC的组内相关系数在不同骨骼部位以及男性同胞对和绝经前及绝经后女性同胞对的不同年龄组之间有所不同，范围为0.228至0.397。在我们的人群中，骨质疏松症的兄弟姐妹复发风险比（λ）为2.6。我们还评估了第一个兄弟姐妹和第二个兄弟姐妹的BMD值与他们较年轻兄弟姐妹低BMD风险（定义为低于同组人群的第10百分位数）的联合关联。如果第一个和第二个兄弟姐妹的BMD均处于最低三分位数，则他们后续兄弟姐妹全身、全髋和腰椎低BMD的比值比（OR）分别为8.32 [95%置信区间（CI）5.59 - 12.39]、8.71（95% CI 5.74 - 13.22）和5.90（95% CI 3.57 - 9.76）。这项研究表明，在大量中国农村成年人样本中，BMD和BMC存在显著的家族聚集性。
