Boulard Mathieu, Bouvet Philippe, Kundu Tapas K, Dimitrov Stefan
Laboratoire Joliot-Curie, CNRS-UMR 5161/INRA 1237/IFR128 Biosciences Lyon-Gerland Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69007 Lyon, France.
Subcell Biochem. 2007;41:71-89.
Histone variant are non-allelic forms of the conventional histones. They are expressed at very low levels compared to their conventional counterparts. All the conventional histones, except H4, have histone variants. Together with histone modifications and chromatin remodeling machines, the incorporation of histone variants into the nucleosome is one of the main strategies that the cell uses to regulate transcription, repair, chromosome assembly and segregation. The exact role of the histone variants in these processes is far from clear, but the emerging picture is that the presence of histone variants confers novel structural and functional properties of the nucleosome which affect the chromatin dynamics. In this article we will discuss the functional significance of histone variants on chromatin function and its link to disease manifestation
组蛋白变体是传统组蛋白的非等位形式。与它们的传统对应物相比，它们的表达水平非常低。除H4外，所有传统组蛋白都有组蛋白变体。组蛋白变体与组蛋白修饰和染色质重塑机器一起，被纳入核小体是细胞用于调节转录、修复、染色体组装和分离的主要策略之一。组蛋白变体在这些过程中的确切作用尚不清楚，但新出现的情况是，组蛋白变体的存在赋予了核小体新的结构和功能特性，从而影响染色质动力学。在本文中，我们将讨论组蛋白变体对染色质功能的功能意义及其与疾病表现的联系。
