Estrada Arthur, LeDuc Patricia A, Curry Ian P, Phelps Shean E, Fuller Daniel R
U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL 36362-0577, USA.
Aviat Space Environ Med. 2007 Apr;78(4):408-13.
Despite many existing treatments, airsickness is an issue of concern for soldiers being transported by helicopter. This experiment examined the efficacy of four airsickness treatments and their effects on performance. This study replicated the transport of soldiers in the cabin of an UH-60 Black Hawk helicopter performing many of the flight maneuvers potentially experienced in a night troop transport during turbulent conditions.
A double-blinded, placebo-controlled design was used to compare the effectiveness of four airsickness countermeasures to their placebo controls. There were 64 male, non-aviator subjects (ages 18-34 yr) who were recruited for the study. Of these, 16 subjects were randomly assigned to each of 4 groups: (1) promethazine (25 mg) + caffeine (200 mg); (2) meclizine (25 mg); (3) Scopolamine patch (1.5 mg); and 4) acustimulation wristband. Each individual participated twice, once with the treatment and once with placebo.
The findings indicated that only the combination of promethazine + caffeine showed a statistically significant reduction in nausea and motion sickness severity, and an improvement in reaction time when compared with its placebo control.
Data from this study indicated that of the countermeasures tested, promethazine + caffeine was the most effective at reducing airsickness while producing the fewest side effects when compared with its placebo. In addition, this study demonstrated that over-the-counter caffeine can serve as an effective stimulant counterpart to promethazine. This may be a more appealing option than employing scheduled sympathomimetic drugs in a combat environment.
尽管现有多种治疗方法,但晕机仍是乘坐直升机的士兵所关注的问题。本实验研究了四种晕机治疗方法的疗效及其对性能的影响。本研究模拟了士兵在UH - 60黑鹰直升机机舱内的运输情况,该直升机执行了许多在夜间部队运输的动荡条件下可能经历的飞行机动动作。
采用双盲、安慰剂对照设计,比较四种晕机对策与其安慰剂对照的有效性。共有64名年龄在18 - 34岁之间的男性非飞行员受试者被招募参加该研究。其中,16名受试者被随机分配到4组中的每组:(1) 异丙嗪(25毫克)+咖啡因(200毫克);(2) 美克洛嗪(25毫克);(3) 东莨菪碱贴片(1.5毫克);以及(4) 穴位刺激腕带。每个个体参加两次实验,一次使用治疗药物,一次使用安慰剂。
研究结果表明,与安慰剂对照相比,只有异丙嗪 + 咖啡因的组合在恶心和晕动病严重程度方面有统计学上的显著降低,并且反应时间有所改善。
本研究数据表明,在所测试的对策中,与安慰剂相比,异丙嗪 + 咖啡因在减轻晕机方面最有效,且副作用最少。此外,本研究表明非处方咖啡因可作为异丙嗪的有效刺激物对应物。在战斗环境中,这可能比使用预定的拟交感神经药物更具吸引力。