Gom Ikuko, Fukushima Hideki, Shiraki Makoto, Miwa Yoshiyuki, Ando Takashi, Takai Kuniyuki, Moriwaki Hisataka
Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
J Nutr Sci Vitaminol (Tokyo). 2007 Feb;53(1):37-42. doi: 10.3177/jnsv.53.37.
While lower serum albumin concentration is often found in the elderly, a relation between serum albumin and age has not been fully elucidated. We conducted population-based cross-sectional and 5-y longitudinal study to examine the relation. A total of 22,705 male and 40,149 female, aged 65 y and older, living in Gifu, participated in the health check service conducted by Gifu City Medical Association. They were self-supported in the activity of daily living and 3,438 of them were followed up every year from 1999 to 2003. Serum albumin levels decreased with age in both men and women. In the cross-sectional study, median value declined from 4.3 g/dL in males aged 65-69 y to 3.9 g/dL in 90< or = y, and 4.3 g/dL to 4.0 g/dL in females. Incidence of hypoalbuminemia (serum albumin < or =3.5 g/dL) increased in parallel with age from 1.2% (65-69 y) to 6.6% (85-89) in males, and 0.6% to 4.1% in females. In the longitudinal study, regression analysis showed a significant decline in serum albumin of 0.015 g/dL per year (r= -0.716) in males, and 0.012 g/ dL per year (r= -0.794) in females. Relative reduction of serum albumin in 5 y was larger in advanced age; 1.2% in females aged 65-69 y and 3.1% in 85-89 y (p<0.05), but not in males. In conclusion, a fall in serum albumin concentration in community-dwelling, self-supported elderly persons was associated significantly with aging.
虽然老年人血清白蛋白浓度通常较低，但血清白蛋白与年龄之间的关系尚未完全阐明。我们进行了基于人群的横断面研究和为期5年的纵向研究来探讨这种关系。岐阜市医学协会对居住在岐阜、年龄在65岁及以上的22705名男性和40149名女性进行了健康检查服务。他们在日常生活中能够自理，其中3438人在1999年至2003年期间每年接受随访。男性和女性的血清白蛋白水平均随年龄增长而下降。在横断面研究中，男性血清白蛋白中位数从65 - 69岁的4.3 g/dL降至90岁及以上的3.9 g/dL，女性从4.3 g/dL降至4.0 g/dL。低白蛋白血症（血清白蛋白≤3.5 g/dL）的发生率随年龄增长而平行上升，男性从1.2%（65 - 69岁）升至6.6%（85 - 89岁），女性从0.6%升至4.1%。在纵向研究中，回归分析显示男性血清白蛋白每年显著下降0.015 g/dL（r = -0.716），女性每年下降0.012 g/dL（r = -0.794）。血清白蛋白在5年中的相对降低幅度在高龄人群中更大；65 - 69岁女性为1.2%，85 - 89岁女性为3.1%（p<0.05），男性则无此情况。总之，社区居住、生活自理的老年人血清白蛋白浓度下降与衰老显著相关。
